The Myc proto-oncogene family consists of three members, C-MYC, MYCN, and MYCL,
which encodes the transcription factor c-Myc (hereafter Myc), N-Myc, and L-Myc …

Oncoproteins of the MYC family are major drivers of human tumorigenesis. Since a large
body of evidence indicates that MYC proteins are transcription factors, studying their function …

The peptidyl-prolyl isomerase, Pin1, is exploited in cancer to activate oncogenes and
inactivate tumor suppressors. However, despite considerable efforts, Pin1 has remained an …

MYC is a master transcriptional regulator that controls almost all cellular processes. Over the
last several decades, researchers have strived to define the context-dependent …

c-Myc (hereafter, Myc) is a cancer driver whose abundance is regulated by the SCFFbw7
ubiquitin ligase and proteasomal degradation. Fbw7 binds to a phosphorylated Myc degron …

Bone mass is maintained by the balance between osteoclast-induced bone resorption and
osteoblast-triggered bone formation. In inflammatory arthritis such as rheumatoid arthritis …

MYC-driven medulloblastomas are highly aggressive childhood brain tumors, however, the
molecular and genetic events triggering MYC amplification and malignant transformation …

Nucleoporin proteins (Nups) have been proposed to mediate spatial and temporal
chromatin organization during gene regulation. Nevertheless, the molecular mechanisms in …

Vascular endothelial cells are located on the surface of the blood vessels. It has been
recognized as an important barrier to the regulation of vascular homeostasis by regulating …

WNT signaling activates MYC expression in cancer cells. Here we report that this involves
an oncogenic super-enhancer-mediated tethering of active MYC alleles to nuclear pores to …