Epstein–Barr virus (EBV) is a ubiquitous human lymphotropic herpesvirus with a well-
established causal role in several cancers. Recent studies have provided compelling …

Epidemiological studies have provided compelling evidence that multiple sclerosis (MS) is a
rare complication of infection with the Epstein–Barr virus (EBV), a herpesvirus that infects …

Increasing evidence indicates the involvement of B cells in the pathogenesis of multiple
sclerosis (MS), but their precise roles are unclear. In this Review, we provide an overview of …

New treatments for multiple sclerosis (MS) focused on B cells have created an atmosphere
of excitement in the MS community. B cells are now known to play a major role in disease …

Historically, multiple sclerosis (MS) has been viewed as being primarily driven by T cells.
However, the effective use of anti-CD20 treatment now also reveals an important role for B …

Although genetic susceptibility explains the clustering of multiple sclerosis (MS) within
families and the sharp decline in risk with increasing genetic distance, it cannot fully explain …

Neurodegeneration, the slow and progressive dysfunction and loss of neurons and axons in
the central nervous system, is the primary pathological feature of acute and chronic …

Objective Prominent inflammation with formation of ectopic B‐cell follicle‐like structures in
the meninges in secondary progressive multiple sclerosis (MS)(SPMS) is associated with …

Growing evidence from cerebrospinal fluid samples and post-mortem brain tissue from
individuals with multiple sclerosis (MS) and rodent models indicates that the meninges have …

This article provides a comprehensive overview of the pathology of multiple sclerosis (MS),
including recent insights into its molecular neuropathology and immunology. It shows that all …