The use of effective regimens for mitigating pain remain underutilized in research rodents
despite the general acceptance of both the ethical imperative and regulatory requirements …

Back-translating the clinical manifestations of human disease burden into animal models is
increasingly recognized as an important facet of preclinical drug discovery. We …

The metabolism cage is a barren, non-enriched, environment, combining a number of
recognized environmental stressors. We investigated the ability of male BALB/c mice to …

This study was conducted to investigate the effects of blood sampling on animal welfare in a
total of 60 NTac: SD rats and 72 C57BL/6NTac mice of both sexes. Blood was sampled …

An adequate analgesic strategy is important to improve the postoperative recovery and
welfare of laboratory rats and mice. It is desirable that the method for administering the drug …

Minimization and alleviation of stress are generally viewed as desirable aspects of
laboratory animal management and use. However, achieving that goal requires an …

In the present investigation, the effect of mercuric chloride on gestation and lactation periods
in mice was studied. The animals were treated with 10 ppm of HgCl 2 and its complications …

Facial vein (cheek blood) and caudal vein (tail blood) phlebotomy are two commonly used
techniques for obtaining blood samples from laboratory mice, while automated blood …

Environmental factors during the early-life period are known to have long-term
consequences for the adult phenotype. An intimate interplay between genes and …

The present study was conducted to assess the animal welfare status of broiler chickens
raised in conventional and welfare-certified farms. One conventional farm (30,000 …