[HTML][HTML] Polyphosphate: a multifunctional metabolite in cyanobacteria and algae

E Sanz-Luque, D Bhaya, AR Grossman - Frontiers in Plant Science, 2020 - frontiersin.org
Polyphosphate (polyP), a polymer of orthophosphate (PO4 3-) of varying lengths, has been
identified in all kingdoms of life. It can serve as a source of chemical bond energy …

Role of phosphate sensing in bone and mineral metabolism

S Chande, C Bergwitz - Nature Reviews Endocrinology, 2018 - nature.com
Inorganic phosphate (Pi) is essential for signal transduction and cell metabolism, and is also
an essential structural component of the extracellular matrix of the skeleton. Pi is sensed in …

[HTML][HTML] The cytoplasmic synthesis and coupled membrane translocation of eukaryotic polyphosphate by signal-activated VTC complex

Z Guan, J Chen, R Liu, Y Chen, Q Xing, Z Du… - Nature …, 2023 - nature.com
Inorganic polyphosphate (polyP) is an ancient energy metabolite and phosphate store that
occurs ubiquitously in all organisms. The vacuolar transporter chaperone (VTC) complex …

[HTML][HTML] ITPK1 is an InsP6/ADP phosphotransferase that controls phosphate signaling in Arabidopsis

E Riemer, D Qiu, D Laha, RK Harmel, P Gaugler… - Molecular Plant, 2021 - cell.com
In plants, phosphate (P i) homeostasis is regulated by the interaction of PHR transcription
factors with stand-alone SPX proteins, which act as sensors for inositol pyrophosphates. In …

[HTML][HTML] Two bifunctional inositol pyrophosphate kinases/phosphatases control plant phosphate homeostasis

J Zhu, K Lau, R Puschmann, RK Harmel, Y Zhang… - Elife, 2019 - elifesciences.org
Many eukaryotic proteins regulating phosphate (Pi) homeostasis contain SPX domains that
are receptors for inositol pyrophosphates (PP-InsP), suggesting that PP-InsPs may regulate …

[HTML][HTML] Inositol pyrophosphate dynamics reveals control of the yeast phosphate starvation program through 1, 5-IP8 and the SPX domain of Pho81

V Chabert, GD Kim, D Qiu, G Liu, LM Mayer, HJ Jessen… - Elife, 2023 - elifesciences.org
Eukaryotic cells control inorganic phosphate to balance its role as essential macronutrient
with its negative bioenergetic impact on reactions liberating phosphate. Phosphate …

Intracellular phosphate sensing and regulation of phosphate transport systems in plants

Z Wang, HF Kuo, TJ Chiou - Plant Physiology, 2021 - academic.oup.com
Recent research on the regulation of cellular phosphate (Pi) homeostasis in eukaryotes has
collectively made substantial advances in elucidating inositol pyrophosphates (PP-InsP) as …

[HTML][HTML] The inositol hexakisphosphate kinases IP6K1 and-2 regulate human cellular phosphate homeostasis, including XPR1-mediated phosphate export

MS Wilson, HJ Jessen, A Saiardi - Journal of Biological Chemistry, 2019 - ASBMB
Phosphate's central role in most biochemical reactions in a living organism requires
carefully maintained homeostasis. Although phosphate homeostasis in mammals has long …

Milestones in understanding transport, sensing, and signaling of the plant nutrient phosphorus

SY Yang, WY Lin, YM Hsiao, TJ Chiou - The Plant Cell, 2024 - academic.oup.com
As an essential nutrient element, phosphorus (P) is primarily acquired and translocated as
inorganic phosphate (Pi) by plant roots. Pi is often sequestered in the soil and becomes …

[HTML][HTML] Emerging trends in nitrogen and phosphorus signalling in photosynthetic eukaryotes

KE Helliwell - Trends in Plant Science, 2023 - cell.com
Phosphorus (P) and nitrogen (N) are the major nutrients that constrain plant and algal
growth in nature. Recent advances in understanding nutrient signalling mechanisms of …