[HTML][HTML] Artificial Intelligence and Multiple Sclerosis

M Amin, E Martínez-Heras, D Ontaneda… - Current Neurology and …, 2024 - Springer
In this paper, we analyse the different advances in artificial intelligence (AI) approaches in
multiple sclerosis (MS). AI applications in MS range across investigation of disease …

Regenerative rehabilitation measures to restore tissue function after arsenic exposure

AA Jasper, KH Shah, H Karim, S Gujral… - Current Opinion in …, 2024 - Elsevier
Environmental exposure of arsenic impairs cardiometabolic profile, skeletal muscle health,
and neurological function. Such declining tissue health is observed as early as in one's …

[HTML][HTML] Mapping the relationship of white matter lesions to depression in multiple sclerosis

EB Baller, EM Sweeney, M Cieslak… - Biological …, 2024 - Elsevier
Background Multiple sclerosis (MS) is an immune-mediated neurological disorder, and up to
50% of patients experience depression. We investigated how white matter network …

[HTML][HTML] Brain age as a biomarker for pathological versus healthy ageing–a REMEMBER study

MMJ Wittens, S Denissen, DM Sima, E Fransen… - Alzheimer's Research & …, 2024 - Springer
Objectives This study aimed to evaluate the potential clinical value of a new brain age
prediction model as a single interpretable variable representing the condition of our brain …

Enlarged perivascular spaces are associated with brain microangiopathy and aging in multiple sclerosis

S Borrelli, F Guisset, C Vanden Bulcke… - Multiple Sclerosis …, 2024 - journals.sagepub.com
Background: Growing evidence links brain-MRI enlarged perivascular spaces (EPVS) and
multiple sclerosis (MS), but their role remains unclear. Objective: This study aimed to …

[HTML][HTML] Analysis of Brain Age Gap across Subject Cohorts and Prediction Model Architectures

L Dular, Ž Špiclin… - Biomedicines, 2024 - mdpi.com
Background: Brain age prediction from brain MRI scans and the resulting brain age gap
(BAG)—the difference between predicted brain age and chronological age—is a general …

[HTML][HTML] BrainAgeNeXt: Advancing Brain Age Modeling for Individuals with Multiple Sclerosis

F La Rosa, JDS Silva, E Dereskewicz, A Invernizzi… - medRxiv, 2024 - ncbi.nlm.nih.gov
Aging is associated with structural brain changes, cognitive decline, and neurodegenerative
diseases. Brain age, an imaging biomarker sensitive to deviations from healthy aging, offers …

Disentangling neurodegeneration from ageing in multiple sclerosis: the brain-predicted disease duration gap

G Pontillo, F Prados, J Colman, B Kanber… - medRxiv, 2024 - medrxiv.org
Disentangling brain ageing from disease-related neurodegeneration in patients with
multiple sclerosis (PwMS) is increasingly topical. The brain-age paradigm offers a window …

Spatiotemporal transcriptomic profiling and modeling of mouse brain at single-cell resolution reveals cell proximity effects of aging and rejuvenation

ED Sun, OY Zhou, M Hauptschein, N Rappoport, L Xu… - bioRxiv, 2024 - biorxiv.org
Old age is associated with a decline in cognitive function and an increase in
neurodegenerative disease risk. Brain aging is complex and accompanied by many cellular …

Neurovirology and Brain Health—A Microglial Perspective

AK Biswas, J Das Sarma - Brain and Mental Health in Ageing, 2024 - Springer
A healthy brain is an explicit prerequisite for exploiting life's full potential. For long,
neurotropic virusinfectionin the CNS has been known to cause immune-mediated …