A deep learning framework for spatiotemporal ultrasound localization microscopy
Ultrasound Localization Microscopy (ULM) can resolve the microvascular bed down to a few
micrometers. To achieve such performance, microbubble contrast agents must perfuse the …
micrometers. To achieve such performance, microbubble contrast agents must perfuse the …
The impact of cocaine on adult hippocampal neurogenesis: potential neurobiological mechanisms and contributions to maladaptive cognition in cocaine addiction …
E Castilla-Ortega, DL de Guevara-Miranda… - Biochemical …, 2017 - Elsevier
After discovering that addictive drugs alter adult neurogenesis, the potential role of adult-
born hippocampal neurons in drug addiction has become a promising research field, in …
born hippocampal neurons in drug addiction has become a promising research field, in …
Alterations in the gut microbiota of rats chronically exposed to volatilized cocaine and its active adulterants caffeine and phenacetin
C Scorza, C Piccini, M Martínez Busi… - Neurotoxicity …, 2019 - Springer
A role of the gut microbiota in influencing brain function and emotional disorders has been
suggested. However, only a few studies have investigated the gut microbiota in the context …
suggested. However, only a few studies have investigated the gut microbiota in the context …
Neurovascular effects of cocaine: relevance to addiction
Cocaine is a highly addictive drug, and its use is associated with adverse medical
consequences such as cerebrovascular accidents that result in debilitating neurological …
consequences such as cerebrovascular accidents that result in debilitating neurological …
Gray‐matter relationships to diagnostic and transdiagnostic features of drug and behavioral addictions
Alterations in neural structure have been reported in both cocaine‐use disorder and
gambling disorder, separately, suggesting similarities across addiction diagnoses. Individual …
gambling disorder, separately, suggesting similarities across addiction diagnoses. Individual …
Automated segmentation and quantification of OCT angiography for tracking angiogenesis progression
Angiogenesis is recognized as a crucial component of many neurovascular diseases such
as stroke, carcinogenesis, and neurotoxicity of abused drug. The ability to track …
as stroke, carcinogenesis, and neurotoxicity of abused drug. The ability to track …
Cocaine's cerebrovascular vasoconstriction is associated with astrocytic Ca2+ increase in mice
Human and animal studies have reported widespread reductions in cerebral blood flow
associated with chronic cocaine exposures. However, the molecular and cellular …
associated with chronic cocaine exposures. However, the molecular and cellular …
Long-term cocaine self-administration produces structural brain changes that correlate with altered cognition
Background An enduring question from cross-sectional clinical studies is whether the
structural and functional differences often observed between cocaine users and healthy …
structural and functional differences often observed between cocaine users and healthy …
Ca2+ channel blockade reduces cocaine's vasoconstriction and neurotoxicity in the prefrontal cortex
C Du, K Park, CP Allen, XT Hu, ND Volkow… - Translational …, 2021 - nature.com
Cocaine profoundly affects both cerebral blood vessels and neuronal activity in the brain.
The vasoconstrictive effects of cocaine, concurrently with its effects on neuronal [Ca2+] i …
The vasoconstrictive effects of cocaine, concurrently with its effects on neuronal [Ca2+] i …
Dynamic 3D imaging of cerebral blood flow in awake mice using self-supervised-learning-enhanced optical coherence Doppler tomography
Cerebral blood flow (CBF) is widely used to assess brain function. However, most preclinical
CBF studies have been performed under anesthesia, which confounds findings. High …
CBF studies have been performed under anesthesia, which confounds findings. High …