Background The concept of digital twins, widely adopted in industry, is entering health care.
However, there is a lack of consensus on what constitutes the digital twin of a patient …

Background Digital twins are computerized patient replicas that allow clinical interventions
testing in silico to minimize preventable patient harm. Our group has developed a novel …

Background and objective Respiratory mechanics of mechanically ventilated patients evolve
significantly with time, disease state and mechanical ventilation (MV) treatment. Existing …

The concept of digital twins, widely adopted in industry, is entering healthcare. In this
scoping review, we analysed definitions and characteristics of patient digital twins being …

Background and objective Healthcare datasets are plagued by issues of data scarcity and
class imbalance. Clinically validated virtual patient (VP) models can provide accurate in …

Mechanical ventilation (MV) parameters and other physiological parameters determined
from mechanically ventilated respiratory failure patients can be used to estimate patient …

Creating multi-level digital-twin models for mechanical ventilation requires a detailed
estimation of regional lung volume. An accurate generic map between 2D chest surface …

Pressure-controlled (PC) ventilation is a pressure-targeted mode of mechanical ventilation
(MV) to prevent barotrauma by using pre-set driving pressures. However, the lack of clinician …

Resource-intensive clinical trial is a crucial step in validating the safety and effectiveness of
personalised, model-based mechanical ventilation (MV) treatments prior to implementation …

There is a need for more individualized treatment of critically ill patients receiving
mechanical ventilation (MV). Therefore, this research aims to create a preliminary multi …