For many years, it has been known that an increase in cytosolic calcium triggers the fusion of
secretory granules and synaptic vesicles with the plasma membrane. However, the role of …

It has been six years since the first reported link between mutations in the cardiac ryanodine
receptor Ca2+ release channel (RyR2) and catecholaminergic polymorphic ventricular …

This review discusses the driving principles that may underlie neurodegeneration in
dementia, represented most dominantly by Alzheimer's disease (AD). While a myriad of …

Leucine-rich repeat kinase 2 (LRRK2) is a gene that, upon mutation, causes autosomal-
dominant familial Parkinson's disease (PD). Yeast two-hybrid screening revealed that …

Cardiac muscle contraction requires sarcoplasmic reticulum (SR) Ca2+ release mediated by
the quaternary complex comprising the ryanodine receptor 2 (RyR2), calsequestrin 2 …

Abstract Adenosine 3′, 5′-cyclic mononucleotide (cAMP) is one of the most important
second messengers which govern cellular signal transductions. Adenylyl cyclases (ACs) …

Brain homeostasis refers to the normal working state of the brain in a certain period, which is
important for overall health and normal life activities. Currently, there is a lack of effective …

The ryanodine receptor (RyR) is an ion channel composed of four identical subunits
mediating calcium efflux from the endo/sarcoplasmic reticulum of excitable and non …

Late endocytic membrane trafficking delivers target materials and newly synthesized
hydrolases into lysosomes and is critical for maintaining an efficient degradation process …

Abstract Two-pore channels (TPC1–3) are recently identified endolysosomal ion channels.
The mechanism by which these channels are regulated at the molecular level is presently …