This review focuses on how blood flow to contracting skeletal muscles is regulated during
exercise in humans. The idea is that blood flow to the contracting muscles links oxygen in …

This review highlights the influence of oxygen (O2) availability on cerebral blood flow (CBF).
Evidence for reductions in O2 content (CaO2) rather than arterial O2 tension (PaO2) as the …

This presentation describes various aspects of the regulation of tissue oxygenation,
including the roles of the circulatory system, respiratory system, and blood, the carrier of …

In 1929 Drury and Szent-Györgyi published a seminal paper describing the potent actions of
adenine compounds. Some decades later, adenosine 5'-triphosphate (ATP) was proposed …

Sepsis induces a wide range of effects on the red blood cell (RBC). Some of the effects
including altered metabolism and decreased 2, 3-bisphosphoglycerate are preventable with …

The discovery of the S‐shaped O2 equilibrium curve and the Bohr effect in 1904 stimulated
a fertile and continued research into respiratory functions of blood and allosteric …

▪ Abstract Blood flow in the microcirculation is regulated by physiological oxygen (O2)
gradients that are coupled to vasoconstriction or vasodilation, the domain of nitric oxide (NO) …

Skeletal muscle blood flow is closely coupled to metabolic demand, and its regulation is
believed to be mainly the result of the interplay of neural vasoconstrictor activity and locally …

Through oxygen-dependent release of the vasodilator ATP, the mobile erythrocyte plays a
fundamental role in matching microvascular oxygen supply with local tissue oxygen …

The microcirculation is a complex and integrated system that supplies and distributes
oxygen throughout the tissues. The red blood cell (RBC) facilitates convective oxygen …