Glioblastoma multiforme (GBM) is a WHO grade IV glioma and the most common malignant,
primary brain tumor with a 5-year survival of 7.2%. Its highly infiltrative nature, genetic …

Glioma is the most common primary cancer of the central nervous system, and around 50%
of patients present with the most aggressive form of the disease, glioblastoma. Conventional …

Importance Oncolytic viruses (OVs) are emerging as important agents in cancer treatment.
Oncolytic viruses offer the attractive therapeutic combination of tumor-specific cell lysis …

Prodrugs are cunning derivatives of therapeutic agents designed to improve the
pharmacokinetics profile of the drug. Within a prodrug, pharmacological activity of the drug is …

Cancer has always been an enormous threat to human health and survival. Surgery,
radiotherapy, and chemotherapy could improve the survival of cancer patients, but most …

Toca 511 (vocimagene amiretrorepvec) is an investigational nonlytic, retroviral replicating
vector (RRV) that delivers a yeast cytosine deaminase, which converts subsequently …

Early-stage clinical trials of oncolytic virotherapy have reported the safety of several virus
platforms, and viruses from three families have progressed to advanced efficacy trials. In …

Among various gene therapy methods for cancer, suicide gene therapy attracts a special
attention because it allows selective conversion of non-toxic compounds into cytotoxic drugs …

This review discusses current clinical advancements in oncolytic viral therapy, with a focus
on the viral platforms approved for clinical use and highlights the benefits each platform …

Abstract In this White Paper, we discuss the current state of microbial cancer therapy. This
paper resulted from a meeting ('Microbial Based Cancer Therapy') at the US National …