Parkinson disease (PD) is a neurodegenerative disorder characterized by motor and non-
motor symptoms which relentlessly and progressively lead to substantial disability and …

Dopamine (DA), as one of the major neurotransmitters in the central nervous system (CNS)
and periphery, exerts its actions through five types of receptors which belong to two major …

Currently approved antidepressant drugs often take months to take full effect, and∼ 30% of
depressed patients remain treatment resistant. In contrast, ketamine, when administered as …

Translational animal models for studying post-traumatic stress disorder (PTSD) are valuable
for elucidating the poorly understood neurobiology of this neuropsychiatric disorder. These …

Introduction Negative symptoms in schizophrenia are associated with poor response to
available treatments, poor quality of life, and functional outcome. Therefore, they represent a …

Schizophrenia is a severe disorder characterized by positive, negative and cognitive
symptoms, which are still not fully understood. The development of efficient antipsychotics …

The dopamine D2 and D3 receptors are implicated in schizophrenia and its
pharmacological treatments. These receptors undergo intracellular trafficking processes that …

Post-traumatic stress disorder (PTSD) is a mental illness developed by vulnerable
individuals exposed to life-threatening events. The pharmacological unresponsiveness …

Cancer is a leading cause of death worldwide, with approximately 19 million new cases
each year. Lately, several novel chemotherapeutic drugs have been introduced, efficiently …

Intestinal organoids are used to analyze the differentiation of enteroendocrine cells (EECs)
and to manipulate their density for treating type 2 diabetes. EEC differentiation is a …