[HTML][HTML] Abdominal aortic aneurysm: roles of inflammatory cells

Z Yuan, Y Lu, J Wei, J Wu, J Yang, Z Cai - Frontiers in immunology, 2021 - frontiersin.org
Abdominal aortic aneurysms (AAAs) are local dilations of infrarenal segment of aortas.
Molecular mechanisms underlying the pathogenesis of AAA remain not fully clear. However …

[HTML][HTML] Abdominal aortic aneurysm formation with a focus on vascular smooth muscle cells

G Qian, O Adeyanju, A Olajuyin, X Guo - Life, 2022 - mdpi.com
Abdominal aortic aneurysm (AAA) is a lethal degenerative vascular disease that affects,
mostly, the elder population, with a high mortality rate (> 80%) upon rupture. It features a …

Genetic and pharmacologic disruption of interleukin-1β signaling inhibits experimental aortic aneurysm formation

WF Johnston, M Salmon, G Su, G Lu… - … , and vascular biology, 2013 - Am Heart Assoc
Objective—Abdominal aortic aneurysms (AAAs) are common, but their exact pathogenesis
remains unknown and no specific medical therapies are available. We sought to evaluate …

The multifaceted functions of CXCL10 in cardiovascular disease

P van den Borne, PHA Quax, IE Hoefer… - BioMed research …, 2014 - Wiley Online Library
C‐X‐C motif ligand 10 (CXCL10), or interferon‐inducible protein‐10, is a small chemokine
belonging to the CXC chemokine family. Its members are responsible for leukocyte …

Role of interleukin-1 signaling in a mouse model of kawasaki disease–associated abdominal aortic aneurysm

D Wakita, Y Kurashima, TR Crother… - … , and vascular biology, 2016 - Am Heart Assoc
Objective—Kawasaki disease (KD) is the most common cause of acquired cardiac disease
in US children. In addition to coronary artery abnormalities and aneurysms, it can be …

Deficiency of cathepsin S attenuates angiotensin II-induced abdominal aortic aneurysm formation in apolipoprotein E-deficient mice

Y Qin, X Cao, J Guo, Y Zhang, L Pan… - Cardiovascular …, 2012 - academic.oup.com
Aims Abdominal aortic aneurysm (AAA) is characterized by extensive aortic wall matrix
degradation that contributes to the remodelling and eventual rupture of the arterial wall …

MMPs and ADAMs/ADAMTS inhibition therapy of abdominal aortic aneurysm

Y Li, W Wang, L Li, RA Khalil - Life sciences, 2020 - Elsevier
Abdominal aortic aneurysm (AAA) is a chronic vascular degenerative disease featured by
progressive dilation and remodeling of the vascular wall, which may lead to aortic rupture …

[HTML][HTML] Intraluminal thrombus: Innocent bystander or factor in abdominal aortic aneurysm pathogenesis?

AJ Boyd - JVS-Vascular Science, 2021 - Elsevier
Abstract Background Abdominal aortic aneurysms (AAAs) represent a complex multifactorial
hemodynamic, thrombotic, and inflammatory process that can ultimately result in aortic …

Risk factors associated with the diagnosis of abdominal aortic aneurysm in patients screened at a regional Veterans Affairs health care system

KC Chun, KY Teng, LAA Chavez, EN Van Spyk… - Annals of vascular …, 2014 - Elsevier
Background An active abdominal aortic aneurysm (AAA) screening program at a regional
Veterans Affairs (VA) health system identifies patients at risk for AAA. The purpose of this …

PKM2 activator TEPP-46 attenuates thoracic aortic aneurysm and dissection by inhibiting NLRP3 inflammasome-mediated IL-1β secretion

S Le, H Zhang, X Huang, S Chen… - Journal of …, 2020 - journals.sagepub.com
Background: The development of thoracic aortic aneurysm and dissection (TAAD) is
mediated by inflammasome activation, which exacerbates the secretion of pro-inflammatory …