Amino acid metabolism in health and disease

ZN Ling, YF Jiang, JN Ru, JH Lu, B Ding… - Signal Transduction and …, 2023 - nature.com
Amino acids are the building blocks of protein synthesis. They are structural elements and
energy sources of cells necessary for normal cell growth, differentiation and function. Amino …

Glutamine: metabolism and immune function, supplementation and clinical translation

V Cruzat, M Macedo Rogero, K Noel Keane, R Curi… - Nutrients, 2018 - mdpi.com
Glutamine is the most abundant and versatile amino acid in the body. In health and disease,
the rate of glutamine consumption by immune cells is similar or greater than glucose. For …

Effect of host genetics on the gut microbiome in 7,738 participants of the Dutch Microbiome Project

EA Lopera-Maya, A Kurilshikov, A van der Graaf, S Hu… - Nature …, 2022 - nature.com
Host genetics are known to influence the gut microbiome, yet their role remains poorly
understood. To robustly characterize these effects, we performed a genome-wide …

Nutritional significance of amino acids, vitamins and minerals as nutraceuticals in poultry production and health–a comprehensive review

M Alagawany, SS Elnesr, MR Farag, R Tiwari… - Veterinary …, 2021 - Taylor & Francis
Nutraceuticals have gained immense importance in poultry science recently considering the
nutritional and beneficial health effects of their constituents. Besides providing nutritional …

Nitric oxide orchestrates metabolic rewiring in M1 macrophages by targeting aconitase 2 and pyruvate dehydrogenase

EM Palmieri, M Gonzalez-Cotto, WA Baseler… - Nature …, 2020 - nature.com
Profound metabolic changes are characteristic of macrophages during classical activation
and have been implicated in this phenotype. Here we demonstrate that nitric oxide (NO) …

Reprogramming of glutamine metabolism and its impact on immune response in the tumor microenvironment

G Ma, Z Zhang, P Li, Z Zhang, M Zeng, Z Liang… - Cell Communication and …, 2022 - Springer
Metabolic reprogramming and immune escape play a major role in tumorigenesis.
Increasing number of studies have shown that reprogramming of glutamine metabolism is a …

Nutrition and wound healing: an overview focusing on the beneficial effects of curcumin

M Barchitta, A Maugeri, G Favara… - International journal of …, 2019 - mdpi.com
Wound healing implicates several biological and molecular events, such as coagulation,
inflammation, migration-proliferation, and remodeling. Here, we provide an overview of the …

Metabolic reprogramming of immune cells in cancer progression

SK Biswas - Immunity, 2015 - cell.com
Immune cells play a key role in host defense against infection and cancer. Upon
encountering danger signals, these cells undergo activation leading to a modulation in their …

Nitric oxide in macrophage immunometabolism: hiding in plain sight

EM Palmieri, C McGinity, DA Wink, DW McVicar - Metabolites, 2020 - mdpi.com
Nitric Oxide (NO) is a soluble endogenous gas with various biological functions like
signaling, and working as an effector molecule or metabolic regulator. In response to …

The roles of glutamine in the intestine and its implication in intestinal diseases

MH Kim, H Kim - International journal of molecular sciences, 2017 - mdpi.com
Glutamine, the most abundant free amino acid in the human body, is a major substrate
utilized by intestinal cells. The roles of glutamine in intestinal physiology and management …