Osteoarthritis (OA) is a progressive degenerative disease resulting in joint deterioration.
Synovial inflammation is present in the OA joint and has been associated with radiographic …

Osteoarthritis (OA) most commonly affects knee joints, and the next most commonly affected
sites are the hands and hips. Three distinct hand OA phenotypes have been described …

Osteoarthritis (OA) is a degenerative disease resulting in irreversible, progressive
destruction of articular cartilage. The etiology of OA is complex and involves a variety of …

MicroRNAs (miRNAs) regulate several physiological and pathological processes involved in
various diseases, including osteoarthritis (OA). OA is the most common global …

Objective To evaluate the efficacy of tocilizumab, an antibody against IL-6 receptor, in
patients with hand osteoarthritis. Methods This was a multicentre, 12-week, randomised …

Background We consider the relationships between a clinical and radiological diagnosis of
knee or hip OA and activities of daily-living (ADL) in older adults. Methods Data were …

Objective Systemic inflammatory factors have been implicated in symptomatic hand
osteoarthritis (OA). Gut microbiome dysbiosis promotes systemic inflammation. The aim of …

Hand osteoarthritis is a common heterogeneous joint disorder with unclear molecular
mechanisms and no disease-modifying drugs. In this study, we performed single-cell RNA …

Abstract Purpose of Review Hand osteoarthritis (hand OA), the most common peripheral
arthritis in the world, is less studied than osteoarthritis (OA) of the knee and hip. However, it …

Osteoarthritis (OA) is a complex musculoskeletal disease and a leading cause of pain and
disability worldwide. Hip and knee OA alone are major contributors to global disability …