Cognitive impairment in multiple sclerosis: clinical management, MRI, and therapeutic avenues

RHB Benedict, MP Amato, J DeLuca… - The Lancet …, 2020 - thelancet.com
Multiple sclerosis is a chronic, demyelinating disease of the CNS. Cognitive impairment is a
sometimes neglected, yet common, sign and symptom with a profound effect on instrumental …

Recommendations for cognitive screening and management in multiple sclerosis care

R Kalb, M Beier, RHB Benedict… - Multiple Sclerosis …, 2018 - journals.sagepub.com
Purpose: To promote understanding of cognitive impairment in multiple sclerosis (MS),
recommend optimal screening, monitoring, and treatment strategies, and address barriers to …

Immunoneuropsychiatry—novel perspectives on brain disorders

K Pape, R Tamouza, M Leboyer, F Zipp - Nature Reviews Neurology, 2019 - nature.com
Immune processes have a vital role in CNS homeostasis, resilience and brain reserve. Our
cognitive and social abilities rely on a highly sensitive and fine-tuned equilibrium of immune …

Treatment and management of cognitive dysfunction in patients with multiple sclerosis

J DeLuca, ND Chiaravalloti, BM Sandroff - Nature Reviews Neurology, 2020 - nature.com
Cognitive impairment is a common and devastating manifestation of multiple sclerosis (MS).
Although disease-modifying therapies have been efficacious for reducing relapse rates in …

Multiple sclerosis and cognition: synaptic failure and network dysfunction

M Di Filippo, E Portaccio, A Mancini… - Nature Reviews …, 2018 - nature.com
Cognitive impairment is increasingly recognized to be a core feature of multiple sclerosis
(MS), with important implications for the everyday life of individuals with MS and for disease …

[HTML][HTML] Cognitive impairment in multiple sclerosis with regards to disease duration and clinical phenotypes

B Brochet, A Ruet - Frontiers in neurology, 2019 - frontiersin.org
The relationships between cognitive impairment that exist during the clinical course of
multiple sclerosis (MS) remain poorly described. The effect of disease duration has been …

[HTML][HTML] Assessment and impact of cognitive impairment in multiple sclerosis: an overview

MÁ Macías Islas, E Ciampi - Biomedicines, 2019 - mdpi.com
Cognitive impairment affects 40–60% of patients with multiple sclerosis. It may be present
early in the course of the disease and has an impact on a patient's employability, social …

[HTML][HTML] Depressive symptoms, anxiety and cognitive impairment: emerging evidence in multiple sclerosis

M Margoni, P Preziosa, MA Rocca, M Filippi - Translational Psychiatry, 2023 - nature.com
Neuropsychiatric abnormalities may be broadly divided in two categories: disorders of
mood, affect, and behavior and abnormalities affecting cognition. Among these conditions …

Distinct cognitive impairments in different disease courses of multiple sclerosis—A systematic review and meta-analysis

A Johnen, NC Landmeyer, PC Bürkner… - Neuroscience & …, 2017 - Elsevier
Cognitive impairment (CI) is common and debilitating in patients with multiple sclerosis.
However, little is known about how different disease courses affect CI, impeding prognosis …

Synaptic elimination in neurological disorders

PL Cardozo, I de Lima, E Maciel… - Current …, 2019 - ingentaconnect.com
Synapses are well known as the main structures responsible for transmitting information
through the release and recognition of neurotransmitters by pre-and post-synaptic neurons …