Mitochondrial potassium channels have been described as important factors in cell pro-life
and death phenomena. The activation of mitochondrial potassium channels, such as ATP …

The field of mitochondrial ion channels underwent a rapid development during the last
decade, thanks to the molecular identification of some of the nuclear-encoded organelle …

The large-conductance calcium-and voltage-activated K+ channel (BKCa) are encoded by
the Kcnma1 gene. They are ubiquitously expressed in neuronal, smooth muscle, astrocytes …

The field of mitochondrial ion channels has undergone a rapid development during the last
three decades, due to the molecular identification of some of the channels residing in the …

Adenosine triphosphate (ATP) is the main energy source in cells and an important
biomolecule participating in cellular reactions in living organisms. Since the ATP level …

Mitochondrial potassium channels control potassium influx into the mitochondrial matrix and
thus regulate mitochondrial membrane potential, volume, respiration, and synthesis of …

Age represents a major risk factor in heart failure (HF). However, the mechanisms linking
ageing and HF are not clear. We aimed to identify the functional, morphological and …

This chapter provides a critical overview of the available literature on the pharmacology of
mitochondrial potassium channels. In the first part, the reader is introduced to the topic, and …

The role of mitochondria goes beyond their capacity to create molecular fuel and includes
eg the production of reactive oxygen species and the regulation of cell death. In endothelial …

Endothelial dysfunction is recognized as a critical condition in the development of
cardiovascular disorders. This multifactorial process involves changes in the biochemical …