Over the past three-decades, Janus kinase (Jak) and signal transducer and activator of
transcription (STAT) signaling has emerged as a paradigm to understand the involvement of …

Tyrosine phosphorylation plays a significant role in a wide range of cellular processes. The
Drosophila genome encodes more than 20 receptor tyrosine kinases and extensive studies …

The Drosophila testis is a well-established system for studying stem cell self-renewal and
competition. In this tissue, the niche supports two stem cell populations, germ line stem cells …

MicroRNAs (miRNAs) are emerging as cooperating factors that promote the activity of
oncogenes in tumor formation and disease progression. This poses the challenge of …

Conserved from humans to Drosophila, the Janus kinase/signal transducer and activators of
transcription (JAK/STAT) signaling cascade is essential for multiple developmental and …

The suppressors of cytokine signaling (SOCS) are a family of intracellular molecules. Many
members of this family have been reported to be involved in various physiological processes …

The conservation of signaling cascades between humans and Drosophila, over more than
500 million years of evolutionary time, means that the genetic tractability of the fly can be …

The compound eye of Drosophila melanogaster consists of individual subunits
(“ommatidia”), each containing photoreceptors and support cells. These cells derive from an …

The importance of signal transduction cascades such as the EGFR and JAK/STAT pathways
for development and homeostasis is highlighted by the high levels of molecular …

The Janus kinase/Signal transducers and activators of transcription (JAK/STAT) pathway
determines cell fates by regulating gene expression. One example is the specification of the …