Causes and consequences of snake venom variation
Snake venoms are mixtures of toxins that vary extensively between and within snake
species. This variability has serious consequences for the management of the world's 1.8 …
species. This variability has serious consequences for the management of the world's 1.8 …
Hybridoma technology a versatile method for isolation of monoclonal antibodies, its applicability across species, limitations, advancement and future perspectives
HA Parray, S Shukla, S Samal, T Shrivastava… - International …, 2020 - Elsevier
The advancements in technology and manufacturing processes have allowed the
development of new derivatives, biosimilar or advanced improved versions for approved …
development of new derivatives, biosimilar or advanced improved versions for approved …
Synthetic development of a broadly neutralizing antibody against snake venom long-chain α-neurotoxins
IS Khalek, RR Senji Laxme, YTK Nguyen… - Science Translational …, 2024 - science.org
Snakebite envenoming is a major global public health concern for which improved therapies
are urgently needed. The antigenic diversity present in snake venom toxins from various …
are urgently needed. The antigenic diversity present in snake venom toxins from various …
Discovery and optimization of a broadly-neutralizing human monoclonal antibody against long-chain α-neurotoxins from snakes
Snakebite envenoming continues to claim many lives across the globe, necessitating the
development of improved therapies. To this end, broadly-neutralizing human monoclonal …
development of improved therapies. To this end, broadly-neutralizing human monoclonal …
Assessing developability early in the discovery process for novel biologics
Beyond potency, a good developability profile is a key attribute of a biological drug.
Selecting and screening for such attributes early in the drug development process can save …
Selecting and screening for such attributes early in the drug development process can save …
Scorpion venom: detriments and benefits
Scorpion venom may cause severe medical complications and untimely death if injected into
the human body. Neurotoxins are the main components of scorpion venom that are known to …
the human body. Neurotoxins are the main components of scorpion venom that are known to …
Bee updated: current knowledge on bee venom and bee envenoming therapy
Honey bees can be found all around the world and fulfill key pollination roles within their
natural ecosystems, as well as in agriculture. Most species are typically docile, and most …
natural ecosystems, as well as in agriculture. Most species are typically docile, and most …
Snakebite envenoming diagnosis and diagnostics
C Knudsen, JA Jürgensen, S Føns, AM Haack… - Frontiers in …, 2021 - frontiersin.org
Snakebite envenoming is predominantly an occupational disease of the rural tropics,
causing death or permanent disability to hundreds of thousands of victims annually. The …
causing death or permanent disability to hundreds of thousands of victims annually. The …
Tissue damaging toxins in snake venoms: Mechanisms of action, pathophysiology and treatment strategies
Snakebite envenoming is an important public health issue responsible for mortality and
severe morbidity. Where mortality is mainly caused by venom toxins that induce …
severe morbidity. Where mortality is mainly caused by venom toxins that induce …
Current research into snake antivenoms, their mechanisms of action and applications
A Silva, GK Isbister - Biochemical society transactions, 2020 - portlandpress.com
Snakebite is a major public health issue in the rural tropics. Antivenom is the only specific
treatment currently available. We review the history, mechanism of action and current …
treatment currently available. We review the history, mechanism of action and current …