The reduction of amides gives access to a wide variety of important compounds such as
amines, imines, enamines, nitriles, aldehydes and alcohols. The chemoselective …

The nucleophilic addition of carbon nucleophiles to amides has traditionally been a difficult
task, both due to reactivity and selectivity problems. When successful, these processes …

The primary objective in synthetic organic chemistry is to develop highly efficient, selective,
and versatile synthetic methodologies, which are essential for discovering new drug …

Conditions for the rapid hydrolysis of chloroform to carbon monoxide (CO) using
heterogeneous CsOH· H2O are described. CO and 13CO can be generated cleanly and …

Amides are ubiquitous in the fine chemical, agrochemical and pharmaceutical industries, but
are rarely exploited as substrates for homologous amine synthesis. By virtue of their high …

A unified total synthesis of stemoamide-type alkaloids is reported. Our synthetic approach
features the chemoselective convergent assembly of five-membered building blocks via …

The first Ir-catalyzed intramolecular asymmetric allylic dearomatization reaction of pyridines,
pyrazines, quinolines, and isoquinolines has been developed. Enabled by in situ formed …

A new iridium catalyzed reductive coupling reaction of Grignard reagents and tertiary
amides affording functionalised tertiary amine products via an efficient and technically …

Amides are a class of easily available compounds, and widely serve as versatile
intermediates in organic synthesis and medicinal chemistry. Amide-based transformations …

Nucleophilic addition to amides has been recognized as a promising transformation for total
synthesis of complex alkaloids. Amides can accept two different organometallic reagents …