Hepatology and drug development for liver diseases require in vitro liver models. Typical
models include 2D planar primary hepatocytes, hepatocyte spheroids, hepatocyte …

The high stiffness of intravenous needles can cause tissue injury and increase the risk of
transmission of blood-borne pathogens through accidental needlesticks. Here we describe …

Background & Aims Sphingosine 1-phosphate receptors (S1PRs) are a group of G-protein–
coupled receptors that confer a broad range of functional effects in chronic inflammatory and …

Chronic alcohol consumption often induces hepatic steatosis but rarely causes severe
inflammation in Kupffer cells (KCs) despite the increased hepatic influx of …

Scope Low circulating 25‐hydroxyvitamin D (25 (OH) D) levels associate with obesity,
diabetes, and hyperlipidemia, but the underlying mechanisms remain uncertain. As energy …

The liver is a complex organ that governs many types of metabolisms, including energy
metabolism and other cellular processes. The liver also plays a crucial role in important …

The efficient nonviral delivery of nucleic acids into the cytoplasm is needed to fully realize
the potential of gene therapy. Although cationic lipids and nanoparticles have been widely …

Although a number of experimental models have been developed for liver research, each
has its own advantages and disadvantages. The present study attempted to develop a …

Non-human primates (NHPs) have played a vital role in fundamental, pre-clinical, and
translational studies because of their high physiological and genetic similarity to humans …

Hepatotoxicity preclinical experiments using animal models have many limitations such as
time consuming, expensive, and mismatching cross-species physiology that affects …