Biomarkers for Alzheimer's disease—preparing for a new era of disease-modifying therapies
H Zetterberg, BB Bendlin - Molecular psychiatry, 2021 - nature.com
Clinical trial results presented in 2019 suggest that antibody-based removal of cerebral
amyloid β (Aβ) plaques may possibly clear tau tangles and modestly slow cognitive decline …
amyloid β (Aβ) plaques may possibly clear tau tangles and modestly slow cognitive decline …
Tau PET imaging in neurodegenerative tauopathies—still a challenge
The accumulation of pathological misfolded tau is a feature common to a collective of
neurodegenerative disorders known as tauopathies, of which Alzheimer's disease (AD) is …
neurodegenerative disorders known as tauopathies, of which Alzheimer's disease (AD) is …
Diagnostic accuracy of a plasma phosphorylated tau 217 immunoassay for Alzheimer disease pathology
Importance Phosphorylated tau (p-tau) is a specific blood biomarker for Alzheimer disease
(AD) pathology, with p-tau217 considered to have the most utility. However, availability of p …
(AD) pathology, with p-tau217 considered to have the most utility. However, availability of p …
18F-MK-6240 PET for early and late detection of neurofibrillary tangles
Braak stages of tau neurofibrillary tangle accumulation have been incorporated in the
criteria for the neuropathological diagnosis of Alzheimer's disease. It is expected that Braak …
criteria for the neuropathological diagnosis of Alzheimer's disease. It is expected that Braak …
18F-flortaucipir PET to autopsy comparisons in Alzheimer's disease and other neurodegenerative diseases
Few studies have evaluated the relationship between in vivo 18F-flortaucipir PET and post-
mortem pathology. We sought to compare antemortem 18F-flortaucipir PET to …
mortem pathology. We sought to compare antemortem 18F-flortaucipir PET to …
A walk through tau therapeutic strategies
S Jadhav, J Avila, M Schöll, GG Kovacs… - Acta neuropathologica …, 2019 - Springer
Tau neuronal and glial pathologies drive the clinical presentation of Alzheimer's disease
and related human tauopathies. There is a growing body of evidence indicating that …
and related human tauopathies. There is a growing body of evidence indicating that …
Diagnostic performance of RO948 F 18 tau positron emission tomography in the differentiation of Alzheimer disease from other neurodegenerative disorders
A Leuzy, R Smith, R Ossenkoppele, A Santillo… - JAMA …, 2020 - jamanetwork.com
Importance The diagnostic performance of second-generation tau positron emission
tomographic (PET) tracers is not yet known. Objective To examine the novel tau PET tracer …
tomographic (PET) tracers is not yet known. Objective To examine the novel tau PET tracer …
[HTML][HTML] Biomarkers for tau pathology
The aggregation of fibrils of hyperphosphorylated and C-terminally truncated microtubule-
associated tau protein characterizes 80% of all dementia disorders, the most common …
associated tau protein characterizes 80% of all dementia disorders, the most common …
TANGO: a placebo-controlled randomized phase 2 study of efficacy and safety of the anti-tau monoclonal antibody gosuranemab in early Alzheimer's disease
M Shulman, J Kong, J O'Gorman, E Ratti… - Nature aging, 2023 - nature.com
In Alzheimer's disease, the spread of aberrantly phosphorylated tau is an important criterion
in the Braak staging of disease severity and correlates with disease symptomatology. Here …
in the Braak staging of disease severity and correlates with disease symptomatology. Here …
A multicentre longitudinal study of flortaucipir (18F) in normal ageing, mild cognitive impairment and Alzheimer's disease dementia
MJ Pontecorvo, MD Devous, I Kennedy, M Navitsky… - Brain, 2019 - academic.oup.com
The advent of tau-targeted PET tracers such as flortaucipir (18F)(flortaucipir, also known as
18F-AV-1451 or 18F-T807) have made it possible to investigate the sequence of …
18F-AV-1451 or 18F-T807) have made it possible to investigate the sequence of …