In this review, we focus on a group of mobile genetic elements designated pathogenicity
islands (PAI). These elements play a pivotal role in the virulence of bacterial pathogens of …

Salmonella enterica serovars cause severe disease in humans, such as gastroenteritis and
typhoid fever. The bacteria are able to invade and replicate within host cells, including …

Salmonellae are important causes of enteric diseases in all vertebrates. Characterization of
the molecular mechanisms that underpin the interactions of salmonellae with their animal …

Type III secretion systems (T3SSs) are complex bacterial structures that provide gram-
negative pathogens with a unique virulence mechanism enabling them to inject bacterial …

Salmonella pathogenesis is dependent on its ability to invade and replicate within host cells.
Following invasion the bacteria remain within a modified phagosome known as the …

Salmonella enterica uses two functionally distinct type III secretion systems encoded on the
pathogenicity islands SPI‐1 and SPI‐2 to transfer effector proteins into host cells. A major …

A variety of intracellular bacteria modulate the host cytoskeleton to establish subcellular
niches for replication. However, the role of intermediate filaments, which are crucial for …

Salmonella enterica serovar Typhimurium (S. Typhimurium) is a Gram‐negative facultative
food‐borne pathogen that causes gastroenteritis in humans. This bacterium has evolved a …

Spi/Ssa is a unique type three secretion system that functions exclusively when Salmonella
enterica is inside eukaryotic cells. Expression of the Spi/Ssa system and its secreted …

SpvC is encoded by the Salmonella virulence plasmid. We have investigated the
biochemical function of SpvC and the mechanism by which it is secreted by bacteria and …