Electrochemical late-stage functionalization

Y Wang, S Dana, H Long, Y Xu, Y Li… - Chemical …, 2023 - ACS Publications
Late-stage functionalization (LSF) constitutes a powerful strategy for the assembly or
diversification of novel molecular entities with improved physicochemical or biological …

Enantioselective radical reactions using chiral catalysts

S Mondal, F Dumur, D Gigmes, MP Sibi… - Chemical …, 2022 - ACS Publications
Benefiting from the impressive increase in fundamental knowledge, the last 20 years have
shown a continuous burst of new ideas and consequently a plethora of new catalytic …

Photoelectrochemical asymmetric catalysis enables site-and enantioselective cyanation of benzylic C–H bonds

CY Cai, XL Lai, Y Wang, HH Hu, J Song, Y Yang… - Nature Catalysis, 2022 - nature.com
The enantioselective functionalization of ubiquitous C (sp 3)–H bonds is ideally suited for
the construction of three-dimensional chiral structures. However, organic molecules often …

Organic electrochemistry: molecular syntheses with potential

C Zhu, NWJ Ang, TH Meyer, Y Qiu… - ACS central …, 2021 - ACS Publications
Efficient and selective molecular syntheses are paramount to inter alia biomolecular
chemistry and material sciences as well as for practitioners in chemical, agrochemical, and …

Copper-catalyzed radical relay in C (sp 3)–H functionalization

Z Zhang, P Chen, G Liu - Chemical Society Reviews, 2022 - pubs.rsc.org
Radical-involved transition metal (TM) catalysis has greatly enabled new reactivities in
recent decades. Copper-catalyzed radical relay offers enormous potential in C (sp3)–H …

Radical C(sp3)–H functionalization and cross-coupling reactions

DL Golden, SE Suh, SS Stahl - Nature Reviews Chemistry, 2022 - nature.com
C–H functionalization reactions are playing an increasing role in the preparation and
modification of complex organic molecules, including pharmaceuticals, agrochemicals and …

Photoelectrochemical asymmetric catalysis enables direct and enantioselective decarboxylative cyanation

XL Lai, M Chen, Y Wang, J Song… - Journal of the American …, 2022 - ACS Publications
The development of efficient and sustainable methods for decarboxylative transformations is
of great importance due to the ease of availability and nontoxicity of carboxylic acids …

Catalyzing electrosynthesis: a homogeneous electrocatalytic approach to reaction discovery

JC Siu, N Fu, S Lin - Accounts of chemical research, 2020 - ACS Publications
Conspectus Electrochemistry has been used as a tool to drive chemical reactions for over
two centuries. With the help of an electrode and a power source, chemists are bestowed with …

A tutorial on asymmetric electrocatalysis

J Rein, SB Zacate, K Mao, S Lin - Chemical Society Reviews, 2023 - pubs.rsc.org
Electrochemistry has emerged as a powerful means to enable redox transformations in
modern chemical synthesis. This tutorial review delves into the unique advantages of …

The persistent radical effect in organic synthesis

D Leifert, A Studer - Angewandte Chemie International Edition, 2020 - Wiley Online Library
Radical–radical couplings are mostly nearly diffusion‐controlled processes. Therefore, the
selective cross‐coupling of two different radicals is challenging and not a synthetically …