The format of the original Hamilton Rating Scale for Depression (HAM-D) was unstructured:
only general instructions were provided for rating individual items. Over the years, a number …

Approximately one-third of individuals in a major depressive episode will not achieve
sustained remission despite multiple, well-delivered treatments. These patients experience …

Objectives. This 2013 update of the practice guidelines for the biological treatment of
unipolar depressive disorders was developed by an international Task Force of the World …

Clinical Psychometrics is an introduction to the long-term attempt to measure the psychiatric
dimension of dementia, schizophrenia, mania, depression, anxiety, neuroticism …

Bupropion has been used as an antidepressant for over 20 years, though its licence for such
use varies and it is typically a third-or fourth-line agent. It has a unique pharmacology …

Background Pharmacological augmentation is a recommended strategy for patients with
treatment-resistant depression. A range of guidelines provide advice on treatment selection …

Background: In a study aimed at identifying the items carrying information regarding the
global severity of depression, the 6-item Hamilton Depression Rating Scale (HAM-D6) was …

Background Although antidepressants are often a first‐line treatment for adults with
moderate to severe depression, many people do not respond adequately to medication, and …

The current generation of antidepressant drugs acts predominantly by targeting the
serotonin transporter (SERT). The original trend to do this selectively (eg, with SSRIs or …

Specific challenges that profoundly affect the outcome of treatment for depression include 1)
patient engagement and retention in care and optimization of treatment adherence, 2) …