As a leading cause of death, second only to heart disease, cancer has always been one of
the burning topics in medical research. When targeting multiple signal pathways in …

Cancer therapy is a growing field, and annually, a high number of research is performed to
develop novel antitumor drugs. Attempts to find new antitumor drugs continue, since cancer …

Novel targets are constantly sought to fight hematologic malignancies. In this regard, high
levels of SIRT2 expression are associated with unfavorable prognosis of acute myeloid …

Differentiation therapy is an alternative strategy used to induce the differentiation of blast
cells toward mature cells and to inhibit tumor cell proliferation for cancer treatment. Nobiletin …

Acute myeloid leukemia (AML) is characterized by the dysregulation of hematopoietic cell
proliferation, resulting in the accumulation of immature myeloid cells in bone marrow. 5 …

8-Hydroxydaidzein (8-OHD, 7, 8, 4′-trihydoxyisoflavone) is a hydroxylated derivative of
daidzein isolated from fermented soybean products. The aim of this study is to investigate …

Background Acute myeloid leukemia (AML) is a heterogeneous clonal disease that prevents
normal myeloid differentiation with its common features. Its incidence increases with age …

A metabolite isolated from fermented soybean, 8-hydroxydaidzein (8-OHD, 7, 8, 4′-
trihydroxyisoflavone, NSC-678112), is widely used in ethnopharmacological research due to …

Gastric cancer rates and fatality rates have not decreased. Gastric cancer treatment has
historically included surgery (both endoscopic and open), chemotherapy, targeted therapy …

Background Radiotherapy is a major treatment for esophageal squamous cell carcinoma
(ESCC). However, HPV infection related radioresistance caused poor prognosis of ESCC …