Beneficial biological effects and the underlying mechanisms of molecular hydrogen-comprehensive review of 321 original articles

M Ichihara, S Sobue, M Ito, M Ito, M Hirayama… - Medical gas …, 2015 - Springer
Therapeutic effects of molecular hydrogen for a wide range of disease models and human
diseases have been investigated since 2007. A total of 321 original articles have been …

[HTML][HTML] Molecular hydrogen: a preventive and therapeutic medical gas for various diseases

L Ge, M Yang, NN Yang, XX Yin, WG Song - Oncotarget, 2017 - ncbi.nlm.nih.gov
Since the 2007 discovery that molecular hydrogen (H 2) has selective antioxidant properties,
multiple studies have shown that H 2 has beneficial effects in diverse animal models and …

Ginsenoside Rb1 inhibits cardiomyocyte autophagy via PI3K/Akt/mTOR signaling pathway and reduces myocardial ischemia/reperfusion injury

GW Qin, P Lu, L Peng, W Jiang - The American Journal of Chinese …, 2021 - World Scientific
Myocardial ischemia/reperfusion injury (MIRI) is the major cause of myocardial cell damage
in acute myocardial infarction, and its treatment remains a clinical challenge. Ginsenoside …

Hydrogen-rich saline attenuated subarachnoid hemorrhage-induced early brain injury in rats by suppressing inflammatory response: possible involvement of NF-κB …

A Shao, H Wu, Y Hong, S Tu, X Sun, Q Wu… - Molecular …, 2016 - Springer
Early brain injury (EBI), highlighted with inflammation and apoptosis, occurring within 72 h
after subarachnoid hemorrhage (SAH), is associated with the prognosis of SAH. Recent …

An updated review of autophagy in ischemic stroke: From mechanisms to therapies

X Wang, Y Fang, Q Huang, P Xu, C Lenahan, J Lu… - Experimental …, 2021 - Elsevier
Stroke is a leading cause of mortality and morbidity worldwide. Understanding the
underlying mechanisms is important for developing effective therapies for treating stroke …

Oxidative stress and pathways of molecular hydrogen effects in medicine

J Slezak, B Kura, TW LeBaron… - Current …, 2021 - ingentaconnect.com
There are many situations of excessive production of reactive oxygen species (ROS) such
as radiation, ischemia/reperfusion (I/R), and inflammation. ROS contribute to and arises from …

miR-21 alleviated apoptosis of cortical neurons through promoting PTEN-Akt signaling pathway in vitro after experimental traumatic brain injury

Z Han, F Chen, X Ge, J Tan, P Lei, J Zhang - Brain research, 2014 - Elsevier
Traumatic brain injury (TBI) is a major cause of chronic disability and death in young adults
worldwide. Multiple cellular, molecular and biochemical changes impact the development …

Autophagy as a cellular stress response mechanism in the nervous system

N Peker, D Gozuacik - Journal of molecular biology, 2020 - Elsevier
Cells of an organism face with various types of insults during their lifetime. Exposure to
toxins, metabolic problems, ischaemia/reperfusion, physical trauma, genetic diseases …

Molecular hydrogen as a neuroprotective agent

M Iketani, I Ohsawa - Current neuropharmacology, 2017 - ingentaconnect.com
Oxidative stress and neuroinflammation cause many neurological disorders. Recently, it has
been reported that molecular hydrogen (H2) functions as an antioxidant and anti …

FoxO proteins in the nervous system

K Maiese - Analytical cellular pathology, 2015 - Wiley Online Library
Acute as well as chronic disorders of the nervous system lead to significant morbidity and
mortality for millions of individuals globally. Given the ability to govern stem cell proliferation …