First variants of the Klebsiella pneumoniae carbapenemase (KPC), KPC-2 and KPC-3, have
encountered a worldwide success, particularly in K. pneumoniae isolates. These beta …

The production of-lactamases is the predominant cause of resistance to-lactam antibiotics in
gram-negative bacteria. These enzymes cleave the amide bond in the-lactam ring …

As a class, the b-lactams are the most commonly prescribed and clinically dependable
antimicrobials in the United States, representing more than 65% of injected antibiotic …

Abstract β-Lactamases are the principal mechanism of bacterial resistance to β-lactam
antibiotics. In recent years the number and variety of new β-lactamases detected has risen at …

The rapid and irrepressible increase in antimicrobial resistance of pathogenic bacteria that
has been observed over the last two decades is widely accepted to be one of the major …

β-Lactamases are the main cause of bacterial resistance to penicillins, cephalosporins and
related β-lactam compounds. These enzymes inactivate the antibiotics by hydrolysing the …

In the last decade the usefulness of the oximino-β-lactams and monobactams has been
compromised by the increasing presence of clinically derived extended-spectrum β …

Antimicrobial resistance genes in pathogenic bacteria belong to the most rapidly evolving
DNA sequences, which results in an enormous structural diversity of resistance effectors …

Objectives The objective of this study was to explore the activity of ceftazidime and
ceftazidime/avibactam against a collection of isogenic strains of Escherichia coli DH10B …

Escherichia coli ILT-1, Klebsiella pneumoniae ILT-2, and K. pneumoniae ILT-3 were isolated
in May 1999 in Paris, France, from a rectal swab of a hospitalized 5-month-old girl. These …