Lysophosphatidic acid (LPA) is an abundant bioactive phospholipid, with multiple functions
both in development and in pathological conditions. Here, we review the literature about the …

Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease of unknown etiology
characterized by distorted distal lung architecture, inflammation, and fibrosis. The molecular …

Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease and a leading
cause of mortality and morbidity worldwide. The aim of this study was to investigate the sex …

Background Idiopathic pulmonary fibrosis (IPF) is a lethal lung disease of unknown etiology.
Patients present loss of lung function, dyspnea and dry cough. Diagnosis requires …

A quarter-century after the discovery of autotaxin in cell culture, the autotaxin-
lysophosphatidate (LPA)-lipid phosphate phosphatase axis is now a promising clinical …

Background Asthma is a chronic respiratory disease with significant heterogeneity in its
clinical presentation and pathobiology. There is need for improved understanding of …

Lysophosphatidic acid (LPA) is a bioactive phospholipid that regulates physiological and
pathological processes in numerous cell biological functions, including cell migration …

Idiopathic pulmonary fibrosis (IPF) is a representative disease that causes fibrosis of the
lungs. Its pathogenesis is thought to be characterized by sustained injury to alveolar …

We developed a mouse model for central post-stroke pain (CPSP), a centrally-originated
neuropathic pain (NeuP). In this mode, mice were first injected with Rose Bengal, followed …

TNFα signaling in the vascular endothelium elicits multiple inflammatory responses that
drive vascular destabilization and leakage. Bioactive lipids are main drivers of these …