Nanopore: Emerging for detecting protein post-translational modifications

X Zhao, H Qin, M Tang, X Zhang, G Qing - TrAC Trends in Analytical …, 2024 - Elsevier
Protein post-translational modifications (PTMs) play pivotal roles in almost every cellular
process, influencing protein stability, localization, interactions, and enzymatic activities. PTM …

Atomistic simulation of molecules interacting with biological nanopores: from current understanding to future directions

A Acharya, JD Prajapati… - The Journal of Physical …, 2022 - ACS Publications
Biological nanopores have been at the focus of numerous studies due to their role in many
biological processes as well as their (prospective) technological applications. Among many …

Cryo-EM structures of human Cx36/GJD2 neuronal gap junction channel

SN Lee, HJ Cho, H Jeong, B Ryu, HJ Lee… - Nature …, 2023 - nature.com
Abstract Connexin 36 (Cx36) is responsible for signal transmission in electrical synapses by
forming interneuronal gap junctions. Despite the critical role of Cx36 in normal brain …

Direct single-molecule detection of CoA-SH and ATP by the membrane proteins TMEM120A and TMEM120B

C Zhao, M Chen, X Liu, W Yuan, K Li, Y Wang, C Chen… - Nanoscale, 2024 - pubs.rsc.org
Membrane proteins are vital resources for developing biosensors. TMEM120A is a
membrane protein associated with human pain transmission and lipid metabolism, and …

Recent advances of nanopore-based analysis for carbohydrate and glycoconjugate

Y Zhao, Z Su, X Zhang, D Wu, Y Wu, G Li - Analytical Methods, 2024 - pubs.rsc.org
Saccharides are not only the basic constituents and nutrients of living organisms, but also
participate in various life activities, and play important roles in cell recognition, immune …

Conformational flexibility driving charge-selective substrate translocation across a bacterial transporter

D Vikraman, BB Majumdar, SK Sharavanakkumar… - Chemical …, 2024 - pubs.rsc.org
Bacterial membrane porins facilitate the translocation of small molecules while restricting
large molecules, and this mechanism remains elusive at the molecular level. Here, we …

[HTML][HTML] Importance of the lysine cluster in the translocation of anions through the pyrophosphate specific channel OprO

C Piselli, VK Golla, R Benz, U Kleinekathöfer - Biochimica et Biophysica …, 2023 - Elsevier
Pseudomonas aeruginosa is a Gram-negative bacterium with an intrinsic resistance towards
antibiotics due to the lack of a large diffusion pores. Exchange of substances with the …

Biphasic concentration patterns in ionic transport under nanoconfinement revealed in steady state and time-dependent properties

M Queralt-Martin, JJ Pérez-Grau, LMA González… - Biophysical …, 2023 - cell.com
Monday, February 20, 2023 223a geometry and chemistry and also the nature of the ionic
solution flowing through it. Accordingly, the concentration at which a given property will …

Translocation of ssDNA through charged graphene nanopores: effect of the charge density

YS Zhang, ZY Qi, MM Ding, ML Li, TF Shi - Chinese Journal of Polymer …, 2024 - Springer
Nanopore sequencing harnesses changes in ionic current as nucleotides traverse a
nanopore, enabling real-time decoding of DNA/RNA sequences. The instruments for the …