VHL and hypoxia signaling: beyond HIF in cancer

J Zhang, Q Zhang - Biomedicines, 2018 - mdpi.com
Von Hippel-Lindau (VHL) is an important tumor suppressor that is lost in the majority of clear
cell carcinoma of renal cancer (ccRCC). Its regulatory pathway involves the activity of E3 …

Molecular interactions and functions of IL-32

KR Aass, MH Kastnes, T Standal - Journal of Leucocyte Biology, 2021 - academic.oup.com
IL-32 is a multifaceted cytokine associated with several diseases and inflammatory
conditions. Its expression is induced in response to cellular stress such as hypoxia …

Insights into the role of IL-32 in cancer

YJE Sloot, JW Smit, LAB Joosten… - Seminars in immunology, 2018 - Elsevier
Abstract Interleukin 32 (IL-32) is a proinflammatory cytokine involved in the development of
several diseases, including cancer. IL-32 is a rather peculiar cytokine because its protein …

[HTML][HTML] Interleukin-32: Frenemy in cancer?

S Han, Y Yang - BMB reports, 2019 - ncbi.nlm.nih.gov
Abstract Interleukin-32 (IL-32) was originally identified in natural killer (NK) cells activated by
IL-2 in 1992. Thus, it was named NK cell transcript 4 (NK4) because of its unknown function …

A critical overview of interleukin 32 in leishmaniases

F Ribeiro-Dias, IBN Oliveira - Frontiers in Immunology, 2022 - frontiersin.org
Interleukin-32 (IL-32) has several immune regulatory properties, which have driven its
investigation in the context of various diseases. IL-32 expression is reported to be induced in …

Ultrasound microbubble-mediated VHL regulates the biological behavior of ovarian cancer cells

C Li, S Hu, Y Yue - Ultrasound in Medicine & Biology, 2021 - Elsevier
According to the literature, the von Hippel–Lindau (VHL) gene has a certain correlation with
ovarian cancer. In this study, we investigated the effect and mechanism of ultrasound …

Toll-like receptor-mediated regulation of IL-32 in multiple myeloma cells

SS Tryggestad - 2020 - ntnuopen.ntnu.no
Myelomatose, eller beinmargskreft, skyldes ukontrollert vekst av maligne plasmaceller i
beinmargen. Pasienter med myelomatose er spesielt utsatt for infeksjoner, som også er en …