Mortality among patients with chronic kidney disease (CKD) is largely a consequence of
cardiovascular disease (CVD) and is a particular concern given the increasing prevalence of …

The CCL2-CCR2 axis is one of the major chemokine signaling pathways that has received
special attention because of its function in the development and progression of …

Among statin-treated patients, inflammation assessed by means of high-sensitivity C-
reactive protein (hsCRP) is a more powerful determinant of cardiovascular death and all …

Myocardial ischemia-reperfusion injury (MIRI) results in the aggravation of myocardial injury
caused by rapid recanalization of the ischemic myocardium. In the past few years, there is a …

Despite the known promotional effects of cigarette smoking on progression of
atherosclerosis (AS), tar as the most dominant toxic component in cigarette smoking has …

The cellular activation of the NLRP3 inflammasome is spatiotemporally orchestrated by
various organelles, but whether lysosomes contribute to this process remains unclear. Here …

Background Inflammation strongly contributes to atherosclerosis initiation and progression.
Consequently, recent clinical trials pharmacologically targeted vascular inflammation to …

With a global burden of 844 million, chronic kidney disease (CKD) is now considered a
public health priority. Cardiovascular risk is pervasive in this population, and low-grade …

Geroscience posits that cardiovascular disease (CVD) and other chronic diseases result
from progressive erosion of the effectiveness of homeostatic mechanisms that oppose age …

Background Inflammation, apoptosis and oxidative stress contribute to the development of
severe acute pancreatitis-associated acute lung injury (SAP-ALI). Currently, there is no …