Predominantly nodal is the most common clinical presentation of peripheral T-(and NK-) cell
lymphomas (PTCL), which comprise three main groups of diseases:(i) systemic anaplastic …

Recent advancements in comprehending peripheral T-cell lymphomas (PTCLs) validate and
broaden our perspective, highlighting their diverse nature and the varying molecular …

DNA methylation-related genes, including TET2, IDH2, and DNMT3A are highly frequently
mutated in angioimmunoblastic T-cell lymphoma (AITL), an aggressive malignancy of T …

T cells are an important component of adaptive immunity and T-cell-derived lymphomas are
very complex due to many functional sub-types and functional elasticity of T-cells. As with …

Background Extensive attention has been given to the role of myeloid-derived suppressor
cells (MDSCs) in driving tumor progression and treatment failure. Preclinical studies have …

Cancer metabolic reprogramming has been recognized as one of the cancer hallmarks that
promote cell proliferation, survival, as well as therapeutic resistance. Up-to-date regulation …

Background For angioimmunoblastic T cell lymphoma (AITL), a rare cancer, no specific
treatments are available and survival outcome is poor. We previously developed a murine …

Peripheral T-cell lymphomas (PTCL) comprised more than 30 rare heterogeneous entities,
representing 10 to 15% of adult non-Hodgkin lymphomas. Although their diagnosis is still …

Background Relapsed or refractory peripheral T-cell lymphomas (r/r PTCLs) are a group of
rare and aggressive diseases that lack effective therapies. Constitutive activation of the …

Angioimmunoblastic T-cell lymphoma (AITL) is an aggressive subtype of peripheral T-cell
lymphomas with its cell origin determined to be follicular helper T-cells. AITL is characterized …