While the processing of mRNA is essential for gene expression, recent findings have
highlighted that RNA processing is systematically altered in cancer. Mutations in RNA …

The genetic information of human cells is stored in the context of chromatin, which is
subjected to DNA methylation and various histone modifications. Such a 'language'of …

More than 80 years ago, the first Polycomb-related phenotype was identified in Drosophila
melanogaster. Later, a group of diverse genes collectively called Polycomb group (PcG) …

Next-generation genomic sequencing has identified multiple novel molecular alterations in
cancer. Since the identification of DNA methylation and histone modification, it has become …

The flexibility of the epigenome has generated an enticing argument to explore its reversion
through pharmacological treatments as a strategy to ameliorate disease phenotypes. All …

Epigenetic dysregulation is a common feature of most cancers, often occurring directly
through alteration of epigenetic machinery. Over the last several years, a new generation of …

Recent genomic studies have resulted in an emerging understanding of the role of
chromatin regulators in the development of cancer. EZH2, a histone methyl transferase …

Our knowledge about the genetics of myelodysplastic syndromes (MDS) and related
myeloid disorders has been dramatically improved during the past decade, in which …

This year is the tenth anniversary of the publication in this journal of a model suggesting the
existence of'tumour progenitor genes'. These genes are epigenetically disrupted at the …

The recent genomic characterization of cancers has revealed recurrent somatic point
mutations and copy number changes affecting genes encoding RNA splicing factors. Initial …