The prevalence of cerebrovascular disease increases with age, placing the elderly at a
greater lifetime risk for dementia. Vascular cognitive impairment (VCI) encompasses a …

Existing drug delivery methods have not led to a significant increase in survival for patients
with malignant primary brain tumors. While the combination of conventional therapies …

Challenges in drug development of neurological diseases remain mainly ascribed to the
blood–brain barrier (BBB). Despite the valuable contribution of animal models to drug …

Neuromyelitis optica (NMO) is a disabling autoimmune astrocytopathy characterized by
typically severe and recurrent attacks of optic neuritis and longitudinally extensive myelitis …

There has been significant progress in our understanding of the pathology and
pathogenesis of central nervous system inflammatory demyelinating diseases …

Diffusion tensor imaging has been used extensively as a research tool to understand the
structural changes associated with white matter pathology. Using water diffusion as the …

Background Neuromyelitis optica (NMO)–IgG is a specific autoantibody marker for NMO. It
binds selectively to aquaporin 4 (AQP4), which is highly concentrated in astrocytic foot …

Neuromyelitis optica (NMO) is an inflammatory demyelinating disease that typically affects
optic nerves and spinal cord. Its pathogenic relationship to multiple sclerosis (MS) is …

We present and discuss the role of endothelial and astroglial cells in managing the blood-
brain barrier (BBB) and aspects of pathological alterations in the BBB. The impact of …

Object The present study investigated the role of hypoxia-inducible factor-1α (HIF-1α),
aquaporin-4 (AQP-4), and matrix metalloproteinase-9 (MMP-9) in blood-brain barrier (BBB) …