Cancer cells can evade immune surveillance in the body. However, immune checkpoint
inhibitors can interrupt this evasion and enhance the antitumor activity of T cells. Other …

Recent studies have demonstrated great therapeutic potential of educating and unleashing
our own immune system for cancer treatment. However, there are still major challenges in …

To enhance the strength of activation afforded by tumor antigen-specific receptors, we
investigated the effect of adding combined CD28 and 4-1BB costimulatory signaling …

Immunostimulatory agents such as agonistic anti-CD137 and interleukin (IL)− 2 generate
effective anti-tumor immunity but also elicit serious toxicities, hampering their clinical …

Photodynamic therapy (PDT) utilizes the destructive power of reactive oxygen species
generated via visible light irradiation of a photosensitive dye accumulated in the cancerous …

We previously demonstrated the feasibility of generating therapeutic numbers of cytotoxic T
lymphocyte (CTL) clones expressing a CD20-specific scFvFc: CD3 ζ chimeric T cell receptor …

Purpose: This study aimed to investigate the biomarkers of sintilimab (anti–PD-1) plus
IBI305 (a bevacizumab biosimilar) in advanced hepatocellular carcinoma (HCC), as well as …

B7-H1 encompasses a recently discovered cell surface glycoprotein within the B7 family of T-
cell coregulatory molecules. B7-H1 expression can be induced on activated T lymphocytes …

The engagement of the herpesvirus entry mediator (HVEM, TNFRSF14) by the B and T
lymphocyte attenuator (BTLA) represents a unique interaction between an activating …

The incidence of pancreatic cancer has been increasing while its 5-year survival rate has
not changed in decades. In the era of personalized medicine, immunotherapy has emerged …