Dynamic nuclear polarization is an emerging technique for increasing the sensitivity of
magnetic resonance imaging and spectroscopy, particularly for low‐γ nuclei. The technique …

This article describes the basic physics of dissolution dynamic nuclear polarization
(dissolution‐DNP), and the impact of the resulting highly nonequilibrium spin states, on the …

Hyperpolarization chemistry based on reversible exchange of parahydrogen, also known as
Signal Amplification By Reversible Exchange (SABRE), is a particularly simple approach to …

Abstract Hyperpolarised MRI with Dynamic Nuclear Polarisation overcomes the fundamental
thermodynamic limitations of conventional magnetic resonance, and is translating to human …

Abstract We report dissolution Dynamic Nuclear Polarization (d‐DNP) of [15N3]
metronidazole ([15N3] MNZ) for the first time. Metronidazole is a clinically approved …

13 C steady state free precession (SSFP) magnetic resonance imaging and effective spin-
spin relaxation time (T2) mapping were performed using hyperpolarized [13 C] urea and [13 …

In recent years there has been an immense development of new targeted anti-cancer drugs.
For practicing precision medicine, a sensitive method imaging for non-invasive, assessment …

In the past decade, hyperpolarized (HP) contrast agents have been under active
development for MRI applications to address the twin challenges of functional and …

Dynamic nuclear polarization and dissolution offer the exciting possibility of imaging
biochemical reactions in vivo, including some of the key enzymatic reactions involved in …

Purpose To develop a high spatiotemporal resolution 3D dynamic pulse sequence for
preclinical imaging of hyperpolarized [1‐13C] pyruvate‐to‐[1‐13C] lactate metabolism at 7T …