Emotional and cognitive impairments in the peripheral nerve chronic constriction injury model (CCI) of neuropathic pain: A systematic review
D Fonseca-Rodrigues, D Amorim, A Almeida… - Behavioural brain …, 2021 - Elsevier
Background and objective Emotional and cognitive impairments are common comorbidities
of chronic neuropathic pain that significantly impact the quality of life of patients. While the …
of chronic neuropathic pain that significantly impact the quality of life of patients. While the …
Chronic pain impact on rodents' behavioral repertoire
AM Cunha, J Pereira-Mendes, A Almeida… - Neuroscience & …, 2020 - Elsevier
Rodent models have been fundamental to understand chronic pain (CP) pathophysiology
and to test for potential treatments. Pain assessment in CP models is most frequently based …
and to test for potential treatments. Pain assessment in CP models is most frequently based …
Cannabidiol modulates chronic neuropathic pain aversion behavior by attenuation of neuroinflammation markers and neuronal activity in the corticolimbic circuit in …
GK Silva-Cardoso, W Lazarini-Lopes, EO Primini… - Behavioural Brain …, 2023 - Elsevier
Chronic neuropathic pain (CNP) is a vast world health problem often associated with the
somatosensory domain. This conceptualization is problematic because, unlike most other …
somatosensory domain. This conceptualization is problematic because, unlike most other …
Cannabidiol in the prelimbic cortex modulates the comorbid condition between the chronic neuropathic pain and depression-like behaviour in rats: The role of medial …
RB Malvestio, P Medeiros, SE Negrini-Ferrari… - Brain Research …, 2021 - Elsevier
The prelimbic division (PrL) of the medial prefrontal cortex (mPFC) is a cerebral division that
is putatively implicated in the chronic pain and depression. We investigated the activity of …
is putatively implicated in the chronic pain and depression. We investigated the activity of …
Camphor attenuates hyperalgesia in neuropathic pain models in mice
Z Li, Y Gan, T Kang, Y Zhao, T Huang… - Journal of Pain …, 2023 - Taylor & Francis
Background The treatment of neuropathic pain is still a major troublesome clinical problem.
The existing therapeutic drugs have limited analgesic effect and obvious adverse reactions …
The existing therapeutic drugs have limited analgesic effect and obvious adverse reactions …
An adapted chronic constriction injury of the sciatic nerve produces sensory, affective, and cognitive impairments: a peripheral mononeuropathy model for the study of …
P Medeiros, IR Dos Santos, IM Júnior, E Palazzo… - Pain …, 2021 - academic.oup.com
Background Chronic constriction injury (CCI) is a model of neuropathic pain induced by four
loose ligatures around the sciatic nerve. This work aimed to investigate the sensory …
loose ligatures around the sciatic nerve. This work aimed to investigate the sensory …
Cortical neurostimulation and N-methyl-D-aspartate glutamatergic receptor activation in the dysgranular layer of the posterior insular cortex modulate chronic …
RCM Pereira, P Medeiros, NC Coimbra… - … : Technology at the …, 2023 - Elsevier
Abstract Background and Aims The dysgranula parts of the posterior insular cortex (PIC)
stimulation (PICS) has been investigated as a new putative cortical target for …
stimulation (PICS) has been investigated as a new putative cortical target for …
CB1-cannabinoid-, TRPV1-vanilloid-and NMDA-glutamatergic-receptor-signalling systems interact in the prelimbic cerebral cortex to control neuropathic pain …
P Medeiros, M Oliveira-Silva, SE Negrini-Ferrari… - Brain Research …, 2020 - Elsevier
Neuropathic pain (NP) is a challenge due to our limited understanding of the mechanisms
that initiate and maintain chronic pain. The prelimbic division (PrL) of the medial prefrontal …
that initiate and maintain chronic pain. The prelimbic division (PrL) of the medial prefrontal …
[HTML][HTML] Co-Combination of Pregabalin and Withania coagulans-Extract-Loaded Topical Gel Alleviates Allodynia and Hyperalgesia in the Chronic Sciatic Nerve …
The current study reports the fabrication of co-combination gel using Pregabalin and
Withania coagulans fruit extract to validate its effectiveness for neuropathic pain in chronic …
Withania coagulans fruit extract to validate its effectiveness for neuropathic pain in chronic …
[HTML][HTML] Exercise facilitates regeneration after severe nerve transection and further modulates neural plasticity
Patients with severe traumatic peripheral nerve injury (PNI) always suffer from incomplete
recovery and poor functional outcome. Physical exercise-based rehabilitation, as a non …
recovery and poor functional outcome. Physical exercise-based rehabilitation, as a non …