The endocytosis mechanism is a complicated system that is essential for cell signaling and
survival. Megalin, a membrane-associated endocytic receptor, and its related proteins such …

Proximal tubule protein uptake is mediated by 2 receptors, megalin and cubilin. These
receptors rescue a variety of filtered ligands, including biomarkers, essential vitamins, and …

The function of the kidney, filtering blood and concentrating metabolic waste into urine, takes
place in an intricate and functionally elegant structure called the renal glomerulus. Normal …

Protein reabsorption is a predominant feature of the renal proximal tubule. Animal studies
show that the ability to rescue plasma proteins relies on the endocytic receptors megalin and …

Albumin is the most abundant protein in blood and acts as a molecular taxi for a plethora of
small insoluble substances such as nutrients, hormones, metals and toxins. In addition, it …

Glomerular endothelium is highly fenestrated, and its contribution to glomerular barrier
function is the subject of debate. In recent years, a polysaccharide-rich endothelial surface …

Receptor-mediated endocytosis in renal proximal tubule epithelial cells (PTECs) is important
for the reabsorption and metabolization of proteins and other substances, including carrier …

Dent disease is a rare genetic proximal tubulopathy which is under-recognized. Its
phenotypic heterogeneity has led to several different classifications of the same disorder, but …

Although APOL1 gene variants are associated with nephropathy in African Americans, little
is known about APOL1 protein synthesis, uptake, and localization in kidney cells. To …

Albumin is the main protein of blood plasma, lymph, cerebrospinal and interstitial fluid. The
protein participates in a variety of important biological functions, such as maintenance of …