Immunotherapy has emerged as a promising treatment paradigm for many malignancies
and is transforming the drug development landscape. Although immunotherapeutic agents …

Natural killer (NK) cells are large granular lymphocytes involved in our defense against
certain virus-infected and malignant cells. In contrast to T cells, NK cells elicit rapid anti …

As one of the most popular laboratory animal models, rodents have been playing crucial
roles in mechanistic investigations of oncogenesis as well as anticancer drug or regimen …

SF3B1 splicing factor mutations are near-universally found in myelodysplastic syndromes
(MDS) with ring sideroblasts (RS), a clonal hematopoietic disorder characterized by …

Proteins created from recurrent fusion genes like CBFB-MYH11 are prevalent in acute
myeloid leukemia (AML), often necessary for leukemogenesis, persistent throughout the …

Since the late 1980s, mice have been repopulated with human hematopoietic cells to study
the fundamental biology of human hematopoiesis and immunity, as well as a broad range of …

Due to the refractory and partial sensitive treatments to malignant cancers, immunotherapy
has increasingly become a hotspot in effective anti-tumor research. However, at present …

Acute myeloid leukemia (AML) initiating and sustaining cells maintain high cell-surface
similarity with their cells-of-origin, ie, hematopoietic stem and progenitor cells (HSPCs), and …

Biological events that contribute to the pathogenesis of myelodysplastic
syndromes/neoplasms (MDS) are becoming increasingly characterized and are being …

As medical and pharmacological technology advances, new and complex modalities of
disease treatment that are more personalized and targeted are being developed. Often …