Abstract Disruption of Akt and Erk-mediated signal transduction significantly contributes in
the pathogenesis of various neurodegenerative diseases (NDs), such as Parkinson's …

Postoperative cognitive dysfunction (POCD) is a common neurological complication
following surgery and general anesthesia, especially in elderly patients. Severe cases delay …

Background Postoperative cognitive decline (POCD) is a recognized clinical phenomenon
characterized by cognitive impairments in patients following anesthesia and surgery, yet its …

Over 60 million people worldwide are diagnosed with glaucomatous optic neuropathy,
which is estimated to be responsible for 8.4 million cases of irreversible blindness globally …

Brain derived neurotrophic factor (BDNF) is well recognized for its neuroprotective functions,
via activation of its high affinity receptor, tropomysin related kinase B (TrkB). In addition …

With the rise in the aging global population, stroke comorbidities have become a serious
health threat and a tremendous economic burden on human society. Current therapeutic …

Glucocorticoids serve as key stress response hormones that facilitate stress coping.
However, sustained glucocorticoid exposure is associated with adverse consequences on …

The pathoetiology and pathophysiology of motor neuron loss in amyotrophic lateral sclerosis
(ALS) are still to be determined, with only a small percentage of ALS patients having a …

Therapies for stroke have remained elusive in the past despite the great relevance of this
pathology. However, recent results have provided strong evidence that postsynaptic density …

Enhancement of brain-derived neurotrophic factor (BDNF) signalling has great potential in
therapy for neurological and psychiatric disorders. This neurotrophin not only attenuates cell …