This article addresses the role of platelet membrane phosphatidylserine (PS) in regulating
the production of thrombin, the central regulatory molecule of blood coagulation. PS is …

Although familial clustering of venous thromboembolic events was observed at the start of
this century, it was not until the late nineteenseventies before our insight into the …

The development of thrombotic disorders in humans is one of the most common causes of
morbidity and mortality in the Western world. Thrombotic disease can be classified in broad …

The protein C system provides important control of blood coagulation by regulating the
activities of factor VIIIa (FVIIIa) and factor Va (FVa), cofactors in the activation of factor X and …

The protein C pathway provides multiple important functions to maintain a regulated balance
between hemostasis and host defense systems in response to vascular and inflammatory …

Blood clot formation to stem bleeding from an injured blood vessel arises from a complex
series of cellular and biochemical events, which, when dysregulated, predispose to an …

A new factor V mutation associated with resistance to activated protein C and thrombosis
(factor V Cambridge, Arg306→ Thr) was found in one patient from a carefully selected group …

Activated protein C (APC) resistance caused by the factor V Leiden mutation is associated
with an increased risk of venous thrombosis. We investigated whether a reduced response …

The protein C anticoagulant pathway converts the coagulation signal generated by thrombin
into an anticoagulant response through the activation of protein C by the thrombin …

Epidemiological studies have shown that women who use third‐generation oral
contraceptives (OC) containing desogestrel, gestodene or norgestimate have a higher risk of …