Proteins are the major component of the living cell. They play crucial roles in the
maintenance of life, and their dysfunctions are known to cause different pathologies. One of …

It has long been axiomatic that a protein's structure determines its function. Intrinsically
disordered proteins (IDPs) and disordered protein regions (IDRs) defy this structure …

The development of methodology for attaching ligand binding sites to proteins of interest has
accelerated biomedical science. Such protein tags have widespread applications as well as …

The scope of the work undertaken in this paper was to explore the feasibility and reliability of
using the Raman signature of aromatic amino acids as a marker in the detection of the …

Many functional proteins do not have well-folded structures in their substantial parts,
representing hybrids that possess both ordered and disordered regions. Disorder is …

Late embryogenesis abundant (LEA) proteins are related to cellular dehydration tolerance.
Most LEA proteins are predicted to have no stable secondary structure in solution, ie, to be …

This Article describes the molecular recognition of peptides containing an N-terminal
methionine (Met) by the synthetic receptor cucurbit [8] uril (Q8) in aqueous solution and with …

Interactions between the aromatic amino acid residues have a significant influence on the
protein structures and protein-DNA complexes. These interactions individually provide little …

IDPs, while structurally poor, are functionally rich by virtue of their flexibility and modularity.
However, how mutations in IDPs elicit diseases, remain elusive. Herein, we have identified …

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by the
degeneration of both upper and lower motor neurons in the brain and spinal cord. ALS is …