Attempts to improve hematopoietic reconstitution and engraftment potential of ex vivo–
expanded hematopoietic stem and progenitor cells (HSPCs) have been largely …

Umbilical cord blood (CB) is a rich source of hematopoietic stem cells (HSCs) with important
applications in allogeneic stem cell transplantation. However, the low numbers of …

The haematopoietic system plays an essential role in our health and survival. It is comprised
of a range of mature blood and immune cell types, including oxygen-carrying erythrocytes …

Hematopoietic stem cell (HSC) transplantation is the only curative therapy for many
diseases. HSCs from umbilical cord blood (UCB) source have many advantages over from …

Chromatin-modifying HDACi exhibit anti-inflammatory properties that reflect their ability to
suppress DC function and enhance regulatory T cells. The influence of HDACi on MDSCs …

Epigenetic therapies, including DNA methyltransferase and histone deacetylase (HDAC)
inhibitors, are increasingly being considered to treat hematological malignancies, but their …

Background: Cord blood (CB) is a promising source for hematopoietic stem cell
transplantations. The limitation of cell dose associated with this source has prompted the ex …

The antiepileptic drug valproic acid (VPA) has been shown to influence the neural
differentiation and neurite outgrowth of neural stem cells. Sympathoadrenal progenitor cells …

Despite increasing knowledge on the regulation of hematopoietic stem/progenitor cell
(HSPC) self-renewal and differentiation, in vitro control of stem cell fate decisions has been …

As caretakers of the hematopoietic system, hematopoietic stem cells assure a lifelong supply
of differentiated populations that are responsible for critical bodily functions, including …