The alternations in the hypoxic and immune microenvironment are closely related to the
therapeutic effect and prognosis of oral squamous cell carcinoma (OSCC). Herein, a new …

High-mobility group box 1 protein (HMGB1) is a highly abundant, non-histone nuclear
protein that can serve as an alarmin to promote the pathogenesis of inflammatory diseases …

Inflammatory skin diseases are a group of diseases caused by the disruption of skin tissue
due to immune system disorders. Histone modification plays a pivotal role in the …

Psoriasis is a recurrent inflammatory skin disease. IL-36-related cytokines are
overexpressed in psoriasis, but the mechanism is not yet clear. Costunolide (Cos) is a …

Cholesteatoma is a specific medical condition involving the abnormal, non-cancerous
growth of skin-like tissue in the middle ear, potentially leading to a collection of debris and …

Dasatinib, a second-generation BCR-ABL inhibitor, is currently used as first-line treatment
for patients with chronic myeloid leukemia. However, dasatinib treatment increases the risk …

Dysregulations of lipid metabolism in the liver may trigger steatosis progression, leading to
potentially severe clinical consequences such as nonalcoholic fatty liver diseases …

The application of lapatinib, a widely used dual inhibitor of human epidermal growth factor
receptor 1 (EGFR/ERBB1) and 2 (HER2/ERBB2), has been seriously limited due to …

Inflammation is vital to protect the host against foreign organism invasion and cellular
damage. However, unresolved chronic inflammation is a recognized precursor and …

Persistent and unresolved inflammation is a common underlying factor observed in several
and seemingly unrelated human diseases, including cardiovascular and neurodegenerative …