Glutamate uptake
NC Danbolt - Progress in neurobiology, 2001 - Elsevier
Brain tissue has a remarkable ability to accumulate glutamate. This ability is due to
glutamate transporter proteins present in the plasma membranes of both glial cells and …
glutamate transporter proteins present in the plasma membranes of both glial cells and …
Mechanisms of glutamate transport
RJ Vandenberg, RM Ryan - Physiological reviews, 2013 - journals.physiology.org
l-Glutamate is the predominant excitatory neurotransmitter in the mammalian central
nervous system and plays important roles in a wide variety of brain functions, but it is also a …
nervous system and plays important roles in a wide variety of brain functions, but it is also a …
Conditional deletion of the glutamate transporter GLT-1 reveals that astrocytic GLT-1 protects against fatal epilepsy while neuronal GLT-1 contributes significantly to …
GLT-1 (EAAT2; slc1a2) is the major glutamate transporter in the brain, and is predominantly
expressed in astrocytes, but at lower levels also in excitatory terminals. We generated a …
expressed in astrocytes, but at lower levels also in excitatory terminals. We generated a …
Structure of a glutamate transporter homologue from Pyrococcus horikoshii
D Yernool, O Boudker, Y Jin, E Gouaux - Nature, 2004 - nature.com
Glutamate transporters are integral membrane proteins that catalyse the concentrative
uptake of glutamate from the synapse to intracellular spaces by harnessing pre-existing ion …
uptake of glutamate from the synapse to intracellular spaces by harnessing pre-existing ion …
Neuronal vs glial glutamate uptake: resolving the conundrum
NC Danbolt, DN Furness, Y Zhou - Neurochemistry international, 2016 - Elsevier
Neither normal brain function nor the pathological processes involved in neurological
diseases can be adequately understood without knowledge of the release, uptake and …
diseases can be adequately understood without knowledge of the release, uptake and …
Molecular biology of mammalian plasma membrane amino acid transporters
M Palacín, R Estévez, J Bertran… - Physiological …, 1998 - journals.physiology.org
Palacı́n, Manuel, Raúl Estévez, Joan Bertran, and Antonio Zorzano. Molecular Biology of
Mammalian Plasma Membrane Amino Acid Transporters. Physiol. Rev. 78: 969–1054, 1998 …
Mammalian Plasma Membrane Amino Acid Transporters. Physiol. Rev. 78: 969–1054, 1998 …
Glioma cells release excitotoxic concentrations of glutamate
ZC Ye, H Sontheimer - Cancer research, 1999 - AACR
Elevated levels of extracellular glutamate ([Glu] o) cause uncontrolled Ca2+ increases in
most neurons and are believed to mediate excitotoxic brain injury following stroke and other …
most neurons and are believed to mediate excitotoxic brain injury following stroke and other …
Synaptic activation of glutamate transporters in hippocampal astrocytes
DE Bergles, CE Jahr - Neuron, 1997 - cell.com
Glutamate transporters in the CNS are expressed in neurons and glia and mediate high
affinity, electrogenic uptake of extracellular glutamate. Although glia have the highest …
affinity, electrogenic uptake of extracellular glutamate. Although glia have the highest …
The SLC1 high-affinity glutamate and neutral amino acid transporter family
Y Kanai, B Clémençon, A Simonin… - Molecular aspects of …, 2013 - Elsevier
Glutamate transporters play important roles in the termination of excitatory
neurotransmission and in providing cells throughout the body with glutamate for metabolic …
neurotransmission and in providing cells throughout the body with glutamate for metabolic …
The glutamate/neutral amino acid transporter family SLC1: molecular, physiological and pharmacological aspects
Y Kanai, MA Hediger - Pflügers Archiv, 2004 - Springer
The solute carrier family 1 (SLC1) includes five high-affinity glutamate transporters, EAAC1,
GLT-1, GLAST, EAAT4 and EAAT5 (SLC1A1, SLC1A2, SLC1A3, SLC1A6, and SLC1A7 …
GLT-1, GLAST, EAAT4 and EAAT5 (SLC1A1, SLC1A2, SLC1A3, SLC1A6, and SLC1A7 …