Endoplasmic reticulum stress: molecular mechanism and therapeutic targets

X Chen, C Shi, M He, S Xiong, X Xia - Signal transduction and targeted …, 2023 - nature.com
The endoplasmic reticulum (ER) functions as a quality-control organelle for protein
homeostasis, or “proteostasis”. The protein quality control systems involve ER-associated …

Mesenchymal stem/stromal cell-based therapy: mechanism, systemic safety and biodistribution for precision clinical applications

WZ Zhuang, YH Lin, LJ Su, MS Wu, HY Jeng… - Journal of biomedical …, 2021 - Springer
Mesenchymal stem/stromal cells (MSCs) are a promising resource for cell-based therapy
because of their high immunomodulation ability, tropism towards inflamed and injured …

Biogenesis, composition and potential therapeutic applications of mesenchymal stem cells derived exosomes in various diseases

YG Yuan, JL Wang, YX Zhang, L Li… - International Journal …, 2023 - Taylor & Francis
Exosomes are nanovesicles with a wide range of chemical compositions used in many
different applications. Mesenchymal stem cell-derived exosomes (MSCs-EXOs) are …

[HTML][HTML] Retinitis pigmentosa: novel therapeutic targets and drug development

KY Wu, M Kulbay, D Toameh, AQ Xu, A Kalevar… - Pharmaceutics, 2023 - mdpi.com
Retinitis pigmentosa (RP) is a heterogeneous group of hereditary diseases characterized by
progressive degeneration of retinal photoreceptors leading to progressive visual decline. It …

Extracellular vesicle therapy for retinal diseases

B Mead, S Tomarev - Progress in retinal and eye research, 2020 - Elsevier
Extracellular vesicles (EV), which include exosomes and microvesicles, are secreted from
virtually every cell. EV contain mRNA, miRNA, lipids and proteins and can deliver this …

Gene therapy strategies for glaucoma from IOP reduction to retinal neuroprotection: Progress towards non-viral systems

A Hakim, B Guido, L Narsineni, DW Chen… - Advanced drug delivery …, 2023 - Elsevier
Glaucoma is the result of the gradual death of retinal ganglion cells (RGCs) whose axons
form the optic nerve. Elevated intraocular pressure (IOP) is a major risk factor that …

Research progress of extracellular vesicles and exosomes derived from mesenchymal stem cells in the treatment of oxidative stress-related diseases

W Zhang, T Wang, Y Xue, B Zhan, Z Lai… - Frontiers in …, 2023 - frontiersin.org
There is growing evidence that mesenchymal stem cell-derived extracellular vesicles and
exosomes can significantly improve the curative effect of oxidative stress-related diseases …

Crosstalk between exosomes and autophagy: a review of molecular mechanisms and therapies

H Xing, J Tan, Y Miao, Y Lv… - Journal of cellular and …, 2021 - Wiley Online Library
Exosomes are extracellular vesicles that primarily exist in bodily fluids such as blood.
Autophagy is an intracellular degradation process, which, along with exosomes, can …

Advances in exosomes‐based drug delivery systems

C Gutierrez‐Millan, C Calvo Díaz… - Macromolecular …, 2021 - Wiley Online Library
Exosomes, a subgroup of extracellular vesicles, are important mediators of long‐distance
intercellular communication and are involved in a diverse range of biological processes …

Human umbilical cord mesenchymal stem cell-derived exosomal miR-27b attenuates subretinal fibrosis via suppressing epithelial–mesenchymal transition by …

D Li, J Zhang, Z Liu, Y Gong, Z Zheng - Stem Cell Research & Therapy, 2021 - Springer
Background and aim Subretinal fibrosis resulting from neovascular age-related macular
degeneration (nAMD) is one of the major causes of serious and irreversible vision loss …