The protein Pal (peptidoglycan-associated lipoprotein) is anchored in the outer membrane
(OM) of Gram-negative bacteria and interacts with Tol proteins. Tol–Pal proteins form two …

Neisseria meningitidis causes most cases of bacterial meningitis. Meningococcal meningitis
is a public health burden to both developed and developing countries throughout the world …

The evolutionarily conserved protein Omp85 is required for outer membrane protein (OMP)
assembly in gram-negative bacteria and in mitochondria. Its Escherichia coli homolog …

The development of a comprehensive vaccine against meningococcal disease has been
challenging. Recent developments in molecular genetics have provided both explanations …

A range of vaccines is available for preventing life-threatening diseases caused by infection
with Neisseria meningitidis (meningococcus, Men). Capsule polysaccharide (CPS) …

Uropathogenic Escherichia coli (UPEC) are the major cause of urinary tract infections. For
successful colonisation of the urinary tract, UPEC employ multiple surface-exposed or …

Streptococcus suis, a zoonotic pathogen, caused serious outbreaks in humans with high
mortality rates in the past decade. To develop safer and more effective vaccines, particularly …

The successful development of vaccines is a lengthy process, requiring input from different
expertises, such as research and development, quality control, quality assurance …

Outer membrane vesicle (OMV)-based vaccines have been used to provide strain-specific
protection against capsular group B Neisseria meningitidis infections, but the full breadth of …

The present invention relates to Neisseria ORF2086 proteins, crossreactive immunogenic
proteins which can be isolated from nesserial strains or prepared recombinantly, including …