Sarcomas are heterogeneous and clinically challenging soft tissue and bone cancers.
Although constituting only 1% of all human malignancies, sarcomas represent the second …

Oncolytic viruses (OVs) preferentially target and kill cancer cells without affecting healthy
cells through a multi-modal mechanism of action. While historically the direct killing activity …

Background Outcomes in children and adolescents with recurrent or progressive high-grade
glioma are poor, with a historical median overall survival of 5.6 months. Pediatric high-grade …

Highlights•Oncolytic viruses (OVs) elicit innate and adaptive immune responses against
tumors.•Although the immune system can react against OVs, a functional immune system is …

Malignant tumors of the central nervous system (CNS) continue to be a leading cause of
cancer-related mortality in both children and adults. Traditional therapies for malignant brain …

Pediatric high-grade brain tumors and adult glioblastoma are associated with significant
morbidity and mortality. Oncolytic herpes simplex virus-1 (oHSV) is a promising approach to …

Purpose: Previously, clinical trials of experimental virotherapy for recurrent glioblastoma
multiforme (GBM) demonstrated that inoculation with a conditionally replication–competent …

Oncolytic virotherapy is an effective immunotherapeutic approach for cancer treatment via a
multistep process including direct tumor cell lysis, induction of cytotoxic or apoptosis …

Ewing sarcoma is a highly aggressive cancer that promotes the infiltration and activation of
pro-tumor M2-like macrophages. Oncolytic virotherapy that selectively infects and destroys …

Brain tumors represent the most common pediatric solid neoplasms and leading cause of
childhood cancer-related morbidity and mortality. Although most adult brain tumors are …