Current challenges in treatment options for visceral leishmaniasis in India: a public health perspective

O Prakash Singh, B Singh, J Chakravarty… - Infectious diseases of …, 2016 - mednexus.org
Visceral leishmaniasis (VL) is a serious parasitic disease causing considerable mortality
and major disability in the Indian subcontinent. It is most neglected tropical disease …

Treatment options for visceral leishmaniasis: a systematic review of clinical studies done in India, 1980–2004

PL Olliaro, PJ Guerin, S Gerstl… - The Lancet infectious …, 2005 - thelancet.com
The state of Bihar in India carries the largest share of the world's burden of antimony-
resistant visceral leishmaniasis. We analysed clinical studies done in Bihar with different …

Liposomal amphotericin B and leishmaniasis: dose and response

S Sundar, J Chakravarty - Journal of global infectious diseases, 2010 - journals.lww.com
Liposomal amphotericin B has been used with increasing frequency to treat visceral
leishmaniasis (VL). It is the treatment of choice for immunocompetent patients in the …

Visceral leishmaniasis in human immunodeficiency virus (HIV)-infected and non-HIV-infected patients: a comparative study

V PINTADO, P Martin-Rabadan, ML RIVERA… - Medicine, 2001 - journals.lww.com
Visceral leishmaniasis (VL) is a severe disease associated with considerable morbidity,
characterized by fever, hepatosplenomegaly, pancytopenia, and hypergammaglobulinemia …

IL-10-and TGF-β-mediated susceptibility in kala-azar and post-kala-azar dermal leishmaniasis: the significance of amphotericin B in the control of Leishmania …

S Saha, S Mondal, R Ravindran… - The Journal of …, 2007 - journals.aai.org
Visceral leishmaniasis (VL) or kala-azar is known to be associated with a mixed Th1-Th2
response, and effective host defense requires the induction of IFN-γ and IL-12. We address …

Species-directed therapy for leishmaniasis in returning travellers: a comprehensive guide

CJ Hodiamont, PA Kager, A Bart… - PLoS neglected …, 2014 - journals.plos.org
Background Leishmaniasis is increasingly reported among travellers. Leishmania species
vary in sensitivity to available therapies. Fast and reliable molecular techniques have made …

Paromomycin in the treatment of leishmaniasis

S Sundar, J Chakravarty - Expert opinion on investigational drugs, 2008 - Taylor & Francis
Background: The treatment options for leishmaniasis are limited. Most of the drugs available
need parenteral administration, are toxic, require monitoring and have a prolonged …

Single-dose liposomal amphotericin B in the treatment of visceral leishmaniasis in India: a multicenter study

S Sundar, TK Jha, CP Thakur, M Mishra… - Clinical infectious …, 2003 - academic.oup.com
Widespread antimony resistance renders conventional amphotericin B the only option for
the treatment of visceral leishmaniasis (VL) in North Bihar, India. Because of its excellent …

Amphotericin versus pentamidine in antimony-unresponsive kala-azar

M Mishra, UK Biswas, DN Jha, AB Khan - The Lancet, 1992 - Elsevier
We compared the efficacy of amphotericin B and pentamidine isethionate in a prospective
randomised trial in 120 uncomplicated and parasitologically confirmed cases of antimony …

Therapeutic options for visceral leishmaniasis

B Monge-Maillo, R López-Vélez - Drugs, 2013 - Springer
Visceral leishmaniasis (VL), also known as Kala-Azar, is a disseminated protozoal infection
caused principally by Leishmania donovani and Leishmania infantum (known as …