Sedentary behavior and physical inactivity are among the leading modifiable risk factors
worldwide for cardiovascular disease and all-cause mortality. The promotion of physical …

We hypothesized that high-intensity aerobic interval training results in a greater beneficial
adaptation of the heart compared with that observed after low-to-moderate exercise …

In the natural habitat of our ancestors, physical activity was not a preventive intervention but
a matter of survival. In this hostile environment with scarce food and ubiquitous dangers …

Exercise training fosters the health and performance of the cardiovascular system, and
represents nowadays a powerful tool for cardiovascular therapy. Exercise exerts its …

In the cardiomyocyte, CaMKII has been identified as a nodal influencer of excitation–
contraction and also excitation–transcription coupling. Its activity can be regulated in …

Although exercise reduces several cardiovascular risk factors associated with
obesity/diabetes, the metabolic effects of exercise on the heart are not well-known. This …

The sarco (endo) plasmic reticulum calcium ATPase (SERCA) is responsible for transporting
calcium (Ca2+) from the cytosol into the lumen of the sarcoplasmic reticulum (SR) following …

The benefits of exercise on the heart are well recognized, and clinical studies have
demonstrated that exercise is an intervention that can improve cardiac function in heart …

For decades, we have known that exercise training exerts beneficial effects on the human
body, and clear evidence is available that a higher fitness level is associated with a lower …

Rationale: In the present study we explored the mechanisms behind excitation–contraction
(EC) coupling defects in cardiomyocytes from mice with type-2 diabetes (db/db). Objective …